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15 p, 1.4 MB |
Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1
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Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Contreras, F. Xabier (Heidelberg University Biochemistry Center (BZH), Heidelberg) ;
Rodríguez Plata, María T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Casas, Josefina (Institut de Química Avançada de Catalunya) ;
Fabriàs, Gemma (Institut de Química Avançada de Catalunya) ;
Kräusslich, Hans Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ;
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes. [...]
2012 -  10.1371/journal.pbio.1001315
PLoS biology, Vol. 10 (april 2012)
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2.
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22 p, 3.3 MB |
The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells
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Badia, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pujantell, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Riveira Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puig, Teresa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Torres Torronteras, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martí, Ramon A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Este, José (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Macrophages are a heterogeneous cell population strongly influenced by differentiation stimuli that become susceptible to HIV-1 infection after inactivation of the restriction factor SAMHD1 by cyclin-dependent kinases (CDK). [...]
2016 - 10.1371/journal.ppat.1005829
PLOS pathogens, Vol. 12 Núm. 8 (August 2016)
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3.
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11 p, 203.3 KB |
Mutations related to Antiretroviral Resistance identified by ultra-deep sequencing in HIV-1 infected children under Structured Interruptions of HAART
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Vázquez Guillén, José Manuel (Universidad Autónoma de Nuevo León (Mèxic)) ;
Palacios Saucedo, Gerardo C. (Instituto Mexicano del Seguro Social) ;
Rivera Morales, Lydia G. (Universidad Autónoma de Nuevo León (Mèxic)) ;
García Campos, Jorge (Instituto Mexicano del Seguro Social) ;
Ortiz López, Rocío (Universidad Autónoma de Nuevo León (Mèxic)) ;
Noguera-Julian, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vielma Ramírez, Herlinda J. (Universidad Autónoma de Nuevo León (Mèxic)) ;
Ramírez, Teresa (Laboratorio Estatal de Salud Pública del Estado de Nuevo León (Mèxic)) ;
Chávez García, Marcelino (Instituto Mexicano del Seguro Social) ;
López Guillén, Paulo (Instituto Mexicano del Seguro Social) ;
Briones Lara, Evangelina (Instituto Mexicano del Seguro Social) ;
Sánchez Sánchez, Luz M. (Instituto Mexicano del Seguro Social) ;
Vázquez Martínez, Carlos A. (Instituto Mexicano del Seguro Social) ;
Rodríguez Padilla, Cristina (Universidad Autónoma de Nuevo León (Mèxic))
Although Structured Treatment Interruptions (STI) are currently not considered an alternative strategy for antiretroviral treatment, their true benefits and limitations have not been fully established. [...]
2016 - 10.1371/journal.pone.0147591
PloS one, Vol. 11 Núm. 1 (January 2016)
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4.
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22 p, 834.8 KB |
EPICE-HIV: An Epidemiologic Cost-Effectiveness Model for HIV Treatment
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Vandewalle, Björn (Exigo Consultores (Lisboa, Portugal)) ;
Llibre Codina, Josep Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Parienti, Jean-Jacques (Côte de Nacre University Hospital (Caen, França)) ;
Ustianowski, Andrew (North Manchester General Hospital) ;
Camacho, Ricardo (Catholic University of Leuven (Bèlgica)) ;
Smith, Colette (University College London) ;
Miners, Alec (London School of Hygiene and Tropical Medicine)) ;
Ferreira, Diana (Exigo Consultores (Lisboa, Portugal)) ;
Félix, Jorge (Exigo Consultores (Lisboa, Portugal))
The goal of this research was to establish a new and innovative framework for cost-effectiveness modeling of HIV-1 treatment, simultaneously considering both clinical and epidemiological outcomes. EPICE-HIV is a multi-paradigm model based on a within-host micro-simulation model for the disease progression of HIV-1 infected individuals and an agent-based sexual contact network (SCN) model for the transmission of HIV-1 infection. [...]
2016 - 10.1371/journal.pone.0149007
PloS one, Vol. 11 Núm. 2 (February 2016)
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5.
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22 p, 7.0 MB |
Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential
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Qualai, Jamal (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Li, Lin-Xi (University of Arkansas for Medical Sciences) ;
Cantero, Jon (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Tarrats, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández Sanmartin, Marco Antonio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sumoy, Lauro (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Rodolosse, Annie (Institute for Research in Biomedicine (IRB Barcelona)) ;
McSorley, Stephen J. (University of California) ;
Genescà Ferrer, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
CD11c is an α integrin classically employed to define myeloid dendritic cells. Although there is little information about CD11c expression on human T cells, mouse models have shown an association of CD11c expression with functionally relevant T cell subsets. [...]
2016 - 10.1371/journal.pone.0154253
PloS one, Vol. 11 Núm. 4 (April 2016)
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6.
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19 p, 1.2 MB |
Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naïve HIV-Infected Individuals
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Blanco-Heredia, Juan (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Lecanda, Aarón (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Valenzuela Ponce, Humberto (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Avila-Rios, Santiago (Instituto Nacional de Enfermedades Respiratorias (México)) ;
Reyes Terán, Gustavo (Instituto Nacional de Enfermedades Respiratorias (México))
Background: therapeutic HIV vaccines may prove helpful to intensify antiretroviral treatment (ART) efficacy and may be an integral part of future cure strategies. Methods: we examined IFN-gamma ELISpot responses to a panel of 218 HIV clade B consensus-based HIV protease-reverse transcriptase peptides, designed to mimic previously described and predicted cytotoxic T lymphocyte epitopes overlapping drug resistance (DR) positions, that either included the consensus sequence or the DR variant sequence, in 49 ART-naïve HIV-infected individuals. [...]
2016 - 10.1371/journal.pone.0147571
PloS one, Vol. 11 Núm. 1 (January 2016)
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7.
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7 p, 617.5 KB |
Identification of Siglec-1 null individuals infected with HIV-1
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Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
McLaren, Paul J. (National HIV and Retrovirology Laboratory (Winnipeg, Canadà)) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martin, Maureen P. (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ;
Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rotger, Margalida (University of Lausanne (Suïssa)) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Wolinsky, Steven M. (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ;
Penugonda, Sudhir (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ;
Günthard, Huldrych F. (University Hospital Zurich (Suïssa)) ;
Fellay, Jacques (École Polytechnique Fédérale de Lausanne (Suïssa)) ;
Carrington, Mary (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Telenti, Amalio (J. Craig Venter Institute (La Jolla, Estats Units d'Amèrica))
Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. [...]
2016 - 10.1038/ncomms12412
Nature communications, Vol. 7 Núm. 12412 (August 2016)
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8.
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23 p, 3.3 MB |
A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
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Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hu, Xintao (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosati, Margherita (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kulkarni, Viraj (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Valentin, Antonio (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Alicea, Cándido (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Pilkington, Guy R. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Sardesai, Niranjan Y. (Inovio Pharmaceuticals) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo Casal, Manuel (Hospital Universitari Vall d'Hebron) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marco, Andrés (Centre Penitenciari d'Homes (Barcelona, Catalunya)) ;
Mullins, James I. (University of Washington (Estats Units d'Amèrica)) ;
Dorrell, Lucy (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Hanke, Tomáš (University of Oxford (Regne Unit)) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pavlakis, George N. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Felber, Barbara K. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
BACKGROUND: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. [...]
2015 - 10.1186/s12967-015-0392-5
Journal of translational medicine, Vol. 13 Núm. 60 (february 2015)
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