1.
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16 p, 2.8 MB |
SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex
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Rasti, George (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Becker, Maximilian (Institut d'Investigació Biomèdica de Bellvitge) ;
Vazquez, Berta N. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Espinosa-Alcantud, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Duran, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gámez-García, Andrés (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ianni, Alessandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gonzalez, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bosch-Presegué, Laia (Institut d'Investigació Biomèdica de Bellvitge) ;
Marazuela Duque, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guitart-Solanes, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Segura-Bayona, Sandra (Institute for Research in Biomedicine (IRB Barcelona)) ;
Bech-Serra, Joan Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Scher, Michael (University of Medicine and Dentistry of New Jersey, USA) ;
Serrano, Lourdes (The City University of New York, USA) ;
Shankavaram, Uma (National Cancer Institute, Bethesda, USA) ;
Erdjument-Bromage, Hediye (University School of Medicine, New York) ;
Tempst, Paul (Memorial Sloan-Kettering Cancer Center, New York) ;
Reinberg, Danny (New York University School of Medicine) ;
Olivella, Mireia (Universitat de Vic. Universitat Central de Catalunya) ;
Stracker, Travis H. (Institute for Research in Biomedicine (IRB Barcelona)) ;
De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The Sirtuin family of NAD+-dependent enzymes plays an important role in maintaining genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). [...]
2023 - 10.1093/nar/gkad504
Nucleic acids research, Vol. 51 Núm. 13 (july 2023) , p. 6754-6769
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2.
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11 p, 1.9 MB |
A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin
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González Miranda, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bosch-Presegué, Laia (Institut de Recerca I Innovació en Ciències de La Vida i de La Salut a La Catalunya Central) ;
Marazuela Duque, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guitart-Solanes, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Espinosa-Alcantud, María Dolores (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernandez, Agustín F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Brown, Jeremy P. (Department of Immunology and Inflammation. The Hammersmith Hospital) ;
Ausió, Juan (University of Victoria. Department of Biochemistry and Microbiology) ;
Vazquez Prat, Berta Nieves (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Singh, Prim B. (Nazarbayev University School of Medicine) ;
Fraga, Mario F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are hallmarks of constitutive heterochromatin that are thought to promote PCH structure through binding to heterochromatin-specific histone modifications and interaction with a wide range of factors. [...]
2023 - 10.3389/fcell.2023.1293122
Frontiers in Cell and Developmental Biology, Vol. 11 (2023) , p. 1293122
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3.
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9 p, 1.5 MB |
Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Musulén, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. [...]
2022 - 10.1080/15592294.2022.2053816
Epigenetics, Vol. 17 Núm. 12 (december 2022) , p. 1677-1685
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4.
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5.
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16 p, 2.3 MB |
SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina
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Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Thackray, J. K. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Simonet, N. G. (Institut d'Investigació Biomèdica de Bellvitge) ;
Chahar, S. (Montpellier Institute of Molecular Genetics (IGMM). CNRS. University of Montpellier) ;
Kane-Goldsmith, N. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Newkirk, S. J. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Lee, S. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Xing, J. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Verzi, M. P. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
An, W. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tischfield, J. A. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Serrano, L. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Universitat Autònoma de Barcelona
Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how this process becomes dysfunctional during aging and in cancer cells is poorly understood. [...]
2019 - 10.1093/nar/gkz519
Nucleic acids research, Vol. 47 Núm. 15 (january 2019) , p. 7870-7885
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6.
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17 p, 1.6 MB |
SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1
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Simonet, Nicolas G.. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Thackray, J. K. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ianni, A. (Max Planck Institute for Heart and Lung Research. Department of Cardiac Development and Remodelling) ;
Espinosa-Alcantud, María Dolores (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morales-Sanfrutos, J. (Universitat Pompeu Fabra) ;
Hurtado-Bagès, Sarah. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sabidó, Eduard (Universitat Pompeu Fabra) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tischfield, J. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
De La Torre Gómez, Gisela Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Braun, T. (Max Planck Institute for Heart and Lung Research. Department of Cardiac Development and Remodelling) ;
Olivella, Mireia (Universitat de Vic. Facultat de Ciències i Tecnologia) ;
Serrano, L. (Department of Science. BMCC. City University of New York (CUNY)) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono-adenosine 5'-diphosphate (ADP)-ribosyltransferase (mADPRT) activity. [...]
2020 - 10.1126/sciadv.aaz2590
Science advances, Vol. 6 Núm. 30 (july 2020) , p. aaz2590
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7.
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16 p, 3.8 MB |
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation
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Serrano, Lourdes (Department of Genetics, the Human Genetics Institute of New Jersey. Rutgers University) ;
Martínez-Redondo, Paloma (Institut d'Investigació Biomèdica de Bellvitge) ;
Marazuela Duque, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
Vazquez Prat, Berta Nieves (Department of Genetics, the Human Genetics Institute of New Jersey. Rutgers University) ;
Dooley, Scott J. (Department of Genetics, the Human Genetics Institute of New Jersey. Rutgers University) ;
Voigt, Philipp (Department of Biochemistry, New York University School of Medicine) ;
Beck, David B. (Department of Biochemistry, New York University School of Medicine) ;
Kane-Goldsmith, Noriko (Department of Genetics, the Human Genetics Institute of New Jersey. Rutgers University) ;
Tong, Qiang (Children's Nutrition Research Center) ;
Rabanal Prados, Rosa Ma. (Rosa Maria) (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Fondevila, Dolors (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Muñoz, Purificación (Institut d'Investigació Biomèdica de Bellvitge) ;
Krüger, Marcus (Max Planck Institute for Heart and Lung Research. Department of Cardiac Development and Remodeling) ;
Tischfield, Jay A. (Department of Genetics, the Human Genetics Institute of New Jersey. Rutgers University) ;
Vaquero, Alejandro (Institut d'Investigació Biomèdica de Bellvitge)
The establishment of the epigenetic mark H4K20me1 (monomethylation of H4K20) by PR-Set7 during G2/M directly impacts S-phase progression and genome stability. However, the mechanisms involved in the regulation of this event are not well understood. [...]
2013 - 10.1101/gad.211342.112
Genes & Development, 2013
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