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Artículos, Encontrados 2 registros
Artículos Encontrados 2 registros  
1.
12 p, 5.0 MB Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient / Saxena, Abhishek (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ; Stevens, Jo (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ; Cetin,Hakan (Nuffield Department of Clinical Neurosciences, John Radcliffe University Hospital, Oxford) ; Koneczny, Inga (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ; Webster, Richard (Nuffield Department of Clinical Neurosciences, John Radcliffe University Hospital, Oxford) ; Lazaridis, Konstantinos (Hellenic Pasteur Institute) ; Tzartos, Socrates (Hellenic Pasteur Institute) ; Vrolix, Kathleen (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ; Nogales-Gadea, Gisela (Institut Germans Trias i Pujol. Recerca Neuromuscular i Neuropediàtrica) ; Machiels, Barbie (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ; Molenaar, Peter C. (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ; Damoiseaux, Jan (Central Diagnostic Laboratory, Maastricht University Medical Center) ; De Baets, Marc H. (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ; Simon-Keller, Katja (Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg) ; Marx, Alexander (Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg) ; Vincent, Angela (Nuffield Department of Clinical Neurosciences, John Radcliffe University Hospital, Oxford) ; Mario Losen (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ; Pilar Martinez-Martinez (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
We report here the sequence and functional characterization of a recombinantly expressed.
autoantibody (mAb 131) previously isolated from a myasthenia gravis patient by immortalization of thymic B cells using Epstein-Barr virus and TLR9 activation. The antibody is characterized by a high degree of somatic mutations as well as a 6 amino acid insertion within the VHCDR2. [...]

2017 - 10.1038/s41598-017-14350-8
Sientific reports, Vol. 7 (october 2017) , p. 1-12  
2.
12 p, 385.6 KB Compromised fidelity of B‐cell tolerance checkpoints in AChR and MuSK myasthenia gravis / Lee, Jae‐Yun (Yale School of Medicine. Department of Neurology) ; Stathopoulos, Panos (Yale School of Medicine. Department of Neurology) ; Gupta, Sasha (Yale School of Medicine. Department of Neurology) ; Bannock, Jason M. (Yale School of Medicine. Department of Immunobiology) ; Barohn, Richard J. (University of Kansas Medical Center. Department of Neurology) ; Cotzomi, Elizabeth (Yale School of Medicine. Department of Neurology) ; Dimachkie, Mazen M. (University of Kansas Medical Center. Department of Neurology) ; Jacobson, Leslie (University of Oxford. Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital) ; Lee, Casey S. (Yale School of Medicine. Department of Neurology) ; Morbach, Henner (Yale School of Medicine. Department of Immunobiology) ; Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ; Shan, Jing‐Li (Yale School of Medicine. Department of Neurology) ; Vander Heiden, Jason A. (Yale University. Interdepartmental Program in Computational Biology and Bioinformatics) ; Waters, Patrick (University of Oxford. Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital) ; Vincent, Angela (University of Oxford. Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital) ; Nowak, Richard J. (Yale School of Medicine. Department of Neurology) ; O'Connor, Kevin C. (Yale School of Medicine. Department of Neurology) ; Universitat Autònoma de Barcelona
Myasthenia gravis () is an autoimmune condition in which neurotransmission is impaired by binding of autoantibodies to acetylcholine receptors (hR) or, in a minority of patients, to muscle specific kinase (Mu). [...]
2016 - 10.1002/acn3.311
Annals of Clinical and Translational Neurology, Vol. 3, Issue 6 (June 2016) , p. 443-454  

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