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1.
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27 p, 6.2 MB |
Immunoregulatory Biomarkers of the Remission Phase in Type 1 Diabetes : miR-30d-5p Modulates PD-1 Expression and Regulatory T Cell Expansion
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Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Armengol, Maria Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alcalde, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Català, Martí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sunye, Sergi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valls, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corripio, Raquel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The partial remission (PR) phase of type 1 diabetes (T1D) is an underexplored period characterized by endogenous insulin production and downmodulated autoimmunity. To comprehend the mechanisms behind this transitory phase and develop precision medicine strategies, biomarker discovery and patient stratification are unmet needs. [...]
2023 -  10.3390/ncrna9020017
Non-Coding RNA, Vol. 9 (february 2023)
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2.
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14 p, 4.8 MB |
Impact of Betamethasone Pretreatment on Engrafment of Cord Blood-Derived Hematopoietic Stem Cells
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Perna-Barrull, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gómez Muñoz, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Rodríguez-Fernández, Silvia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gieras, Anna (University Medical Center Hamburg-Eppendorf) ;
Ampudia Carrasco, Rosa María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Almenara-Fuentes, Lidia (Ahead Therapeutics SL (Barcelona, Espanya)) ;
Risueño, Ruth M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Querol, Sergi (Institut Germans Trias i Pujol. Banc de Sang i Teixits) ;
Tolosa, Eva (University Medical Center Hamburg-Eppendorf) ;
Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Hematopoietic stem cell (HSC) transplantation is crucial to cure hematologic malignancies. Umbilical cord blood (UCB) is a source of stem cells, but 90% of UCB units are discarded due to low cellularity. [...]
2022 - 10.1007/s00005-022-00666-5
Archivum Immunologiae et Therapiae Experimentalis, Vol. 71 (december 2022)
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3.
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8 p, 885.1 KB |
Fast-screening flow cytometry method for detecting nanoplastics in human peripheral blood
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Salvia, Roser (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
G. Rico, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bradford, Jolene A. (Thermo Fisher Scientific (Estats Units d'Amèrica)) ;
Ward, Michael D. (Thermo Fisher Scientific (Estats Units d'Amèrica)) ;
Olszowy, Michael W. (Sartorius Stedim North America (Estas Units d'Amèrica)) ;
Martínez Martínez, Cristina (Institut de Recerca Biomèdica de Lleida) ;
Madrid, Alvaro (Sant Joan de Deu Research Institute) ;
Grífols, Joan R. (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Ancochea, Águeda (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Gómez Muñoz, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sorigue, Marc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Petriz, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Plastic pollution is a global problem. Animals and humans can ingest and inhale plastic particles, with uncertain health consequences. Nanoplastics (NPs) are particles ranging from 1 nm to 1000 nm that result from the erosion or breakage of larger plastic debris, and can be highly polydisperse in physical properties and heterogeneous in composition. [...]
2023 - 10.1016/j.mex.2023.102057
MethodsX, Vol. 10 (february 2023)
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4.
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23 p, 12.1 MB |
Candidate Biomarkers for the Prediction and Monitoring of Partial Remission in Pediatric Type 1 Diabetes
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Gómez Muñoz, Laia (Institut Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Caroz-Armayones, Josep M. (The Johns Hopkins University - Pompeu Fabra University Public Policy Center) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Valls, Aina (Institut Germans Trias i Pujol) ;
Vázquez, Federico (Institut Germans Trias i Pujol) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corripio, Raquel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Castaño, Luis (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Bel, Joan (Institut Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol)
The partial remission (PR) phase, a period experienced by most patients with type 1 diabetes (T1D) soon after diagnosis, is characterized by low insulin requirements and improved glycemic control. Given the great potential of this phase as a therapeutic window for immunotherapies because of its association with immunoregulatory mechanisms and β-cell protection, our objective was to find peripheral immunological biomarkers for its better characterization, monitoring, and prediction. [...]
2022 - 10.3389/fimmu.2022.825426
Frontiers in immunology, Vol. 13 (february 2022)
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5.
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8 p, 689.8 KB |
Prenatal Betamethasone Exposure and its Impact on Pediatric Type 1 Diabetes Mellitus : A Preliminary Study in a Spanish Cohort
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Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Real, Nati (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bel, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Betamethasone, a glucocorticoid used to induce lung maturation when there is a risk of preterm delivery, can affect the immune system maturation and type 1 diabetes (T1D) incidence in the progeny. It has been described that prenatal betamethasone protects offspring from experimental T1D development. [...]
2022 - 10.1155/2022/6598600
Journal of Diabetes Research, Vol. 2022 (march 2022)
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6.
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15 p, 4.5 MB |
Minimum Information about T Regulatory Cells : A Step toward Reproducibility and Standardization
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Fuchs, Anke (Technische Universität Dresden, Germany) ;
Gliwiński, Mateusz (Medical University of Gdańsk, Poland) ;
Grageda, Nathali (MRC Centre for Transplantation, King's College London, Guy's Hospital) ;
Spiering, Rachel (Newcastle University) ;
Abbas, Abul K. (University of California, San Francisco) ;
Appel, Silke (University of Bergen, Norway) ;
Bacchetta, Rosa (Stanford School of Medicine, United States) ;
Battaglia, Manuela (San Raffaele Hospital, Milan) ;
Berglund, David (Uppsala University, Sweden) ;
Blazar, Bruce (University of Minnesota, United States) ;
Bluestone, Jeffrey A. (University of California, San Francisco, United States) ;
Bornhäuser, Martin (Technische Universität Dresden, Germany) ;
ten Brinke, Anja (University of Amsterdam) ;
Brusko, Todd M. (University of Florida Diabetes Institute) ;
Cools, Nathalie (University Hospital Antwerp (Bèlgica)) ;
Cuturi, Maria Cristina (Université de Nantes) ;
Geissler, Edward (University Hospital Regensburg, Germany) ;
Giannoukakis, Nick (Carnegie Mellon University, Pittsburgh, United States) ;
Gołab, Karolina (The University of Chicago, United States) ;
Hafler, David A. (Yale School of Medicine, New Haven, United States) ;
van Ham, S. Marieke (University of Amsterdam) ;
Hester, Joanna (University of Oxford) ;
Hippen, Keli (University of Minnesota, United States) ;
Di Ianni, Mauro (University of Chieti-Pescara) ;
Ilic, Natasa (University of Belgrade) ;
Isaacs, John (National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University) ;
Issa, Fadi (University of Oxford) ;
Iwaszkiewicz-Grzes, Dorota (Medical University of Gdańsk, Poland) ;
Jaeckel, Elmar (Department of Gastroenterology, Hepatology, Endocrinology, Diabetology, Transplantationsforschungszentrum, Medical School of Hannover (MHH)) ;
Joosten, Irma (Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboudumc, Netherlands) ;
Klatzmann, David (Hôpital Pitié-Salpêtrière, Paris) ;
Koenen, Hans (Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboudumc, Netherlands) ;
van Kooten, Cees (Leiden University Medical Center, Netherlands) ;
Korsgren, Olle (Gothenburg University, Sweden) ;
Kretschmer, Karsten (University Hospital and Medical Faculty Carl Gustav Carus of TU Dresden, Germany) ;
Levings, Megan (The University of British Columbia, Vancouver, Canada) ;
Marek-Trzonkowska, Natalia Maria (Medical University of Gdańsk, Poland) ;
Martinez-Llordella, Marc (King's College London) ;
Miljkovic, Djordje (University of Belgrade) ;
Mills, Kingston H. G. (Trinity College Dublin, Ireland) ;
Miranda, Joana P. (Universidade de Lisboa) ;
Piccirillo, Ciriaco A. (Research Institute of McGill University Health Centre, Montréal, Canada) ;
Putnam, Amy L. (University of California, San Francisco) ;
Ritter, Thomas (National University of Ireland) ;
Roncarolo, Maria Grazia (Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, ISCBRM, Stanford School of Medicine) ;
Sakaguchi, Shimon (Osaka University, Japan) ;
Sánchez-Ramón, Silvia (Hospital Clínico San Carlos (Madrid)) ;
Sawitzki, Birgit (Humboldt-Universität zu Berlin) ;
Sofronic-Milosavljevic, Ljiljana (University of Belgrade) ;
Sykes, Megan (University of California, San Francisco) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Waldmann, Herman (University of Oxford) ;
Witkowski, Piotr (The University of Chicago) ;
Wood, Kathryn J. (University of Oxford) ;
Gregori, Silvia (San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute IRCCS) ;
Hilkens, Catharien M. U. (Newcastle University) ;
Lombardi, Giovanna (MRC Centre for Transplantation, King's College London, Guy's Hospital) ;
Lord, Phillip (School of Computing, Newcastle University) ;
Martinez-Caceres, Eva Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Trzonkowski, Piotr (Medical University of Gdańsk, Poland)
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. [...]
2018 - 10.3389/fimmu.2017.01844
Frontiers in immunology, Vol. 8 (january 2018)
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7.
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9 p, 721.8 KB |
Immune System Remodelling by Prenatal Betamethasone : Effects on β-Cells and Type 1 Diabetes
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Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gieras, Anna (University Medical Center Hamburg-Eppendorf) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tolosa, Eva (University Medical Center Hamburg-Eppendorf) ;
Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Type 1 diabetes (T1D) is a multifactorial disease of unknown aetiology. Studies focusing on environment-related prenatal changes, which might have an influence on the development of T1D, are still missing. [...]
2020 - 10.3389/fendo.2020.00540
Frontiers in Endocrinology, Vol. 11 (august 2020)
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8.
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14 p, 1.8 MB |
NK Cell Subsets Changes in Partial Remission and Early Stages of Pediatric Type 1 Diabetes
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Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol) ;
Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corripio, Raquel (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Bel, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes (T1D) is a chronic metabolic disease characterized by the autoimmune destruction of β-cells in the pancreatic islets. T1D is preceded by islet-specific inflammation led by several immune cells. [...]
2021 - 10.3389/fimmu.2020.611522
Frontiers in immunology, Vol. 11, art. 611522 (january 2021)
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9.
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11 p, 4.3 MB |
Antigen-specific immunotherapy combined with a regenerative drug in the treatment of experimental type 1 diabetes
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Villalba Felipe, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ;
Gómez Muñoz, Laia (Institut Germans Trias i Pujol) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Aguilera, Eva (Institut Germans Trias i Pujol) ;
Risueño, Ruth M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vázquez, Federico (Institut Germans Trias i Pujol) ;
Vives-Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. To revert type 1 diabetes, the suppression of the autoimmune attack should be combined with a β-cell replacement strategy. [...]
2020 - 10.1038/s41598-020-76041-1
Scientific reports, Vol. 10 (2020) , art. 18927
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10.
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2 p, 318.1 KB |
Dendritic cells from paediatric patients with type 1 diabetes show altered phagocytosis capacity correlating with disease evolution
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Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Bel, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol)
Autoimmunity against β-cells in type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) play a crucial role as orchestrators of the immune response. [...]
2019 - 10.1007/s00125-019-4946-6
Diabetologia, Vol. 62, supl. 1 (Set. 2019) , art. S224
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