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10 p, 859.5 KB |
Predicting AT(N) pathologies in Alzheimer's disease from blood-based proteomic data using neural networks
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Zhang, Y. (University of Oxford) ;
Ghose, U. (University of Oxford) ;
Buckley, N.J. (University of Oxford) ;
Engelborghs, S. (Vrije Universiteit Brussel) ;
Sleegers, K. (University of Antwerp) ;
Frisoni, G.B. (Department of Psychiatry. University of Geneva) ;
Wallin, A. (University of Gothenburg) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, J. (University of Zürich) ;
Martinez-Lage, P. (CITA-Alzheimer Foundation) ;
Legido-Quigley, C. (Steno Diabetes Center) ;
Barkhof, F. (University College London) ;
Zetterberg, H. (Kong Kong Center for Neurodegenerative Diseases) ;
Visser, P.J. (VU University Medical Center) ;
Bertram, L. (University of Oslo) ;
Lovestone, S. (Janssen RD) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Shi, L. (University of Oxford) ;
Universitat Autònoma de Barcelona
Background and objective: Blood-based biomarkers represent a promising approach to help identify early Alzheimer's disease (AD). Previous research has applied traditional machine learning (ML) to analyze plasma omics data and search for potential biomarkers, but the most modern ML methods based on deep learning has however been scarcely explored. [...]
2022 -  10.3389/fnagi.2022.1040001
Frontiers in aging neuroscience, Vol. 14 (29 2022) , p. 1040001
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13 p, 396.5 KB |
The ecosystem of health decision making : from fragmentation to synergy
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Schünemann, H.J. (Humanitas University) ;
Reinap, M. (WHO Regional Office for Europe) ;
Piggott, T. (McMaster University) ;
Laidmäe, E. (Estonian Health Insurance Fund) ;
Köhler, K. (WHO Country Office in Estonia) ;
Pōld, M. (University of Tartu) ;
Ens, B. (Canadian Agency for Drugs and Technology in Health) ;
Irs, A. (Tartu University Hospital) ;
Akl, E.A. (American University of Beirut) ;
Cuello, C.A. (Canadian Agency for Drugs and Technology in Health) ;
Falavigna, M. (Federal University of Rio Grande do Sul) ;
Gibbens, M. (Canadian Agency for Drugs and Technology in Health) ;
Neamtiu, L. (Joint Research Centre. European Commission) ;
Parmelli, E. (Joint Research Centre. European Commission) ;
Jameleddine, M. (National Authority for Assessment and Accreditation in Healthcare) ;
Pyke, L. (Canadian Agency for Drugs and Technology in Health) ;
Verstijnen, I. (National Health Care Institute) ;
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Tugwell, P. (University of Ottawa) ;
Zhang, Y. (Michael G. McMaster University) ;
Saz-Parkinson, Z. (Instituto de Salud Carlos III) ;
Kuchenmüller, T. (WHO) ;
Moja, L. (WHO) ;
Universitat Autònoma de Barcelona
Clinicians, patients, policy makers, funders, programme managers, regulators, and science communities invest considerable amounts of time and energy in influencing or making decisions at various levels, using systematic reviews, health technology assessments, guideline recommendations, coverage decisions, selection of essential medicines and diagnostics, quality assurance and improvement schemes, and policy and evidence briefs. [...]
2022 - 10.1016/S2468-2667(22)00057-3
The Lancet public health, Vol. 7 Núm. 4 (april 2022) , p. e378-e390
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12 p, 963.9 KB |
Mechanical ventilation in patients with cardiogenic pulmonary edema : a sub-analysis of the LUNG SAFE study
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Amado-Rodríguez, Laura (Centro de Investigación Biomédica en Red (CIBER)-Enfermedades Respiratorias) ;
Rodríguez-Garcia, Raquel (Centro de Investigación Biomédica en Red (CIBER)-Enfermedades Respiratorias) ;
Albaiceta, Guillermo M. ;
Pham, Tài (Université Paris-Saclay) ;
Fan, Eddy (University of Toronto) ;
Madotto, Fabiana (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ;
Laffey, John G. ;
Pesenti, A. ;
Brochard, L. ;
Esteban, A. ;
Gattinoni, Luciano ;
Van Haren, Frank ;
Larsson, Anders ;
McAuley, Daniel F. ;
Ranieri, Marco ;
Rubenfeld, Gordon ;
Taylor Thompson, B. ;
Wrigge, Hermann ;
Slutsky, Arthur S. ;
Rios, Fernando ;
Van Haren, Frank ;
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Depuydt, Pieter ;
Lora, Fredy S. ;
Azevedo, Luciano Cesar ;
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Qiu, Haibo ;
Gonzalez, Marcos ;
Silesky, Juan ;
Cerny, Vladimir ;
Nielsen, Jonas ;
Jibaja, Manuel ;
Wrigge, Hermann ;
Matamis, Dimitrios ;
Ranero, Jorge Luis ;
Amin, Pravin ;
Hashemian, S.M. ;
Clarkson, Kevin ;
Kurahashi, Kyyoyasu ;
Villagomez, Asisclo ;
Zeggwagh, Amine Ali 700 1_ ;
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Las Lomas, Sanatorio ;
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Elatrous, S. ;
Bouchoucha, S. ;
Chouchene, I. ;
Ouanes, I. ;
Souissi, A.B. ;
Kamoun, S. ;
Demirkiran, O. ;
Aker, M. ;
Erbabacan, E. ;
Ceylan, I. ;
Girgin, N.K. ;
Ozcelik, M. ;
Ünal, N. ;
Meco, B.C. ;
Akyol, O.O. ;
Derman, S.S. ;
Kennedy, B. ;
Parhar, K. ;
Srinivasa, L. ;
McNamee, L. ;
Hopkins, P. ;
Mellis, C. ;
Kakar, V. ;
Hadfield, D. ;
Vercueil, A. ;
Bhowmick, K. ;
Humphreys, S.K. ;
Ferguson, A. ;
Mckee, R. ;
Raj, A.S. ;
Fawkes, D.A. ;
Watt, P. ;
Twohey, L. ;
Jha, R.R. ;
Thomas, M. ;
Morton, A. ;
Kadaba, V. ;
Smith, M.J. ;
Hormis, A.P. ;
Kannan, S.G. ;
Namih, M. ;
Reschreiter, H. ;
Camsooksai, J. ;
Kumar, A. ;
Rugonfalvi, S. ;
Nutt, C. ;
Oneill, O. ;
Seasman, C. ;
Dempsey, G. ;
Scott, C.J. ;
Ellis, H.E. ;
Mckechnie, S. ;
Hutton, P.J. ;
Di Tomasso, N.N. ;
Vitale, M.N. ;
Griffin, R.O. ;
Dean, M.N. ;
Cranshaw, J.H. ;
Willett, E.L. ;
Ioannou, N. ;
Gillis, S. ;
Csabi, P. ;
Macfadyen, R. ;
Dawson, H. ;
Preez, P.D. ;
Williams, A.J. ;
Boyd, O. ;
de Gordoa, L.O.R. ;
Bramall, J. ;
Symmonds, S. ;
Chau, S.K. ;
Wenham, T. ;
Szakmany, T. ;
Toth-Tarsoly, P. ;
McCalman, K.H. ;
Alexander, P. ;
Stephenson, L. ;
Collyer, T. ;
Chapman, R. ;
Cooper, R. ;
Allan, R.M. ;
Sim, M. ;
Wrathall, D.W. ;
Irvine, D.A. ;
Zantua, C.K.S. ;
Adams, J.C. ;
Burtenshaw, A.J. ;
Sellors, G.P. ;
Welters, I.D. ;
Williams, K.E. ;
Hessell, R.J. ;
Oldroyd, M.G. ;
Battle, C.E. ;
Pillai, S. ;
Kajtor, I. ;
Sivashanmugavel, M. ;
Okane, S.C. ;
Donnelly, A. ;
Frigyik, A.D. ;
Careless, J.P. ;
May, M.M. ;
Stewart, R. ;
Trinder, T.J. ;
Hagan, S.J. ;
Cole, J.M. ;
MacFie, C.C. ;
Dowling, A.T. ;
Hurtado, J. ;
Nin, N. ;
Hurtado, J. ;
Nuñez, E. ;
Pittini, G. ;
Rodriguez, R. ;
Imperio, M.C. ;
Santos, C. ;
França, A.G. ;
Ebeid, A. ;
Deicas, A. ;
Serra, C. ;
Uppalapati, A. ;
Kamel, G. ;
BannerGoodspeed, V.M. ;
Beitler, J.R. ;
Mukkera, S.R. ;
Kulkarni, S. ;
Shinn, J.O. ;
Gomaa, D. ;
Tainter, C. ;
Lee, J. ;
Mesar, T. ;
Yeatts, D.J. ;
Warren, J. ;
Lanspa, M.J. ;
Miller, R.R. ;
Grissom, C.K. ;
Brown, S.M. ;
Bauer, P.R. ;
Gosselin, R.J. ;
Kitch, B.T. ;
Cohen, J.E. ;
Beegle, S.H. ;
Choudry, S. ;
Gueret, R.M. ;
Tulaimat, A. ;
Stigler, W. ;
Batra, H. ;
Huff, N.G. ;
Lamb, K.D. ;
Oetting, T.W. ;
Mohr, N.M. ;
Judy, C. ;
Saito, S. ;
Kheir, F.M. ;
Kheir, F. ;
Schlichting, A.B. ;
Delsing, A. ;
Crouch, D.R. ;
Elmasri, M. ;
Crouch, D.R. ;
Ismail, D. ;
Dreyer, K.R. ;
Blakeman, T.C. ;
Gomaa, D. ;
Baro, R.M. ;
Hou, P.C. ;
Seethala, R. ;
Aisiku, I. ;
Henderson, G. ;
Frendl, G. ;
Hou, S.K. ;
Owens, R.L. ;
Schomer, A. ;
Universitat Autònoma de Barcelona
Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. [...]
2022 - 10.1186/s40560-022-00648-x
Journal of Intensive Care, Vol. 10 Núm. 1 (01 2022) , p. 55
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5.
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33 p, 20.4 MB |
Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells
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Zhang, Yu Wei (University of Freiburg, Germany) ;
Mess, Julian (University of Freiburg, Germany) ;
Aizarani, Nadim (University of Freiburg, Germany) ;
Mishra, Pankaj (University of Freiburg, Germany) ;
Johnson, Carys (University of Cambridge, UK) ;
Romero-Mulero, Mari Carmen (University of Freiburg, Germany) ;
Rettkowski, Jasmin (University of Freiburg, Germany) ;
Schönberger, Katharina (University of Freiburg, Germany) ;
Obier, Nadine (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Jäcklein, Karin (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Woessner, Nadine M. (University of Freiburg, Germany) ;
Lalioti, Maria Eleni (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Velasco-Hernandez, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sikora, Katarzyna (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Wäsch, Ralph (University of Freiburg, Germany) ;
Lehnertz, Bernhard (University of Montreal, Canada) ;
Sauvageau, Guy (University of Montreal, Canada) ;
Manke, Thomas (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Menendez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Walter, Sebastian Gottfried (University Hospital of Cologne, Germany) ;
Minguet, Susana (University of Freiburg, Germany) ;
Laurenti, Elisa (University of Cambridge, UK) ;
Günther, Stefan (University of Freiburg, Germany) ;
Grün, Dominic (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Cabezas-Wallscheid, Nina (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany)
Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied by dormant HSCs, which reversibly exit quiescence during stress. [...]
2022 - 10.1038/s41556-022-00931-x
Nature Cell Biology, Vol. 24 Núm. 7 (july 2022) , p. 1038-1048
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6.
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14 p, 2.7 MB |
GPRC5C drives branched-chain amino acid metabolism in leukemogenesis
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Zhang, Yu Wei (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mess, Julian (University of Freiburg) ;
Lalioti, Maria Eleni (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Romero-Mulero, Mari Carmen (University of Freiburg, Germany) ;
Obier, Nadine (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Karantzelis, Nikolaos (University Medical Center Freiburg, Germany) ;
Rettkowski, Jasmin (University of Freiburg, Germany) ;
Schönberger, Katharina (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Karabacz, Noemie (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Jäcklein, Karin (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Morishima, Tatsuya (Kumamoto University, Japan) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Romecin, Paola (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martinez, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Takizawa, Hitoshi (Kumamoto University, Japan) ;
Shoumariyeh, Khalid (University of Freiburg, Germany) ;
Renders, Simon (Heidelberg University Hospital (Alemanya)) ;
Zeiser, Robert (University of Freiburg, Germany) ;
Pahl, Heike L. (University Medical Center Freiburg, Germany) ;
Béliveau, François (Quebec leukemia cell bank. Hopital Maisonneuve-Rosemont, Montreal, Canada) ;
Hébert, Josee (Quebec leukemia cell bank. Hopital Maisonneuve-Rosemont, Montreal, Canada) ;
Lehnertz, Bernhard (University of Montreal, Canada) ;
Sauvageau, Guy (University of Montreal, Canada) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cabezas-Wallscheid, Nina (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany)
Leukemia stem cells (LSCs) share numerous features with healthy hematopoietic stem cells (HSCs). G-protein coupled receptor family C group 5 member C (GPRC5C) is a regulator of HSC dormancy. However, GPRC5C functionality in acute myeloid leukemia (AML) is yet to be determined. [...]
2023 - 10.1182/bloodadvances.2023010460
Blood advances, Vol. 7 Núm. 24 (december 2023) , p. 7525-7538
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7.
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9 p, 439.9 KB |
Development and use of a content search strategy for retrieving studies on patients' views and preferences
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Selva, A. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Solà, Ivan (Institut d'Investigació Biomèdica Sant Pau) ;
Zhang, Y. (McMaster University (Canadà)) ;
Pardo-Hernandez, Hector (Institut d'Investigació Biomèdica Sant Pau) ;
Haynes, R.B. (McMaster University (Canadà)) ;
Martínez García, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Navarro, T. (McMaster University (Canadà)) ;
Schünemann, H. (McMaster University (Canadà)) ;
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Identifying scientific literature addressing patients' views and preferences is complex due to the wide range of studies that can be informative and the poor indexing of this evidence. Given the lack of guidance we developed a search strategy to retrieve this type of evidence. [...]
2017 - 10.1186/s12955-017-0698-5
Health and quality of life outcomes, Vol. 15 Núm. 1 (30 2017) , p. 126
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8.
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15 p, 707.5 KB |
Recent global decline of CO2 fertilization effects on vegetation photosynthesis
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Wang, Songhan (Nanjing University. International Institute for Earth System Science) ;
Zhang, Yongguang (Nanjing University. International Institute for Earth System Science) ;
Ju, Weimin (Nanjing University. International Institute for Earth System Science) ;
Chen, Jing M. (Nanjing University. International Institute for Earth System Science) ;
Ciais, Philippe (Centre National de la Recherche Scientifique. Laboratoire des Sciences du Climat et de l'Environnement) ;
Cescatti, Alessandro (European Commission. Joint Research Centre) ;
Sardans i Galobart, Jordi (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Janssens, Ivan (University of Antwerp. Centre of Excellence PLECO) ;
Wu, Mousong (Nanjing University. International Institute for Earth System Science) ;
Berry, Joseph A. (Carnegie Institution for Science. Department of Global Ecology (USA)) ;
Campbell, Elliott (University of California. Sierra Nevada Research Institute) ;
Fernández-Martínez, Marcos (University of Antwerp. Centre of Excellence PLECO) ;
Alkama, Ramdane (European Commission. Joint Research Centre) ;
Sitch, Stephen (University of Exeter. College of Life and Environmental Sciences) ;
Friedlingstein, Pierre (University of Exeter. College of Engineering, Mathematics and Physical Sciences) ;
Smith, William K. (University of Arizona. School of Natural Resources and the Environment) ;
Yuan, Wenping (Sun Yat-Sen University. Center for Monsoon and Environment Research) ;
He, Wei (Nanjing University. International Institute for Earth System Science) ;
Lombardozzi, Danica (National Center for Atmospheric Research (USA)) ;
Kautz, Markus (Forest Research Institute Baden-Württemberg) ;
Zhu, Dan (Centre National de la Recherche Scientifique. Laboratoire des Sciences du Climat et de l'Environnement) ;
Lienert, Sebastian (University of Bern. Oeschger Centre for Climate Change Research) ;
Kato, Etsushi (Institute of Applied Energy (Japan)) ;
Poulter, Benjamin (NASA Goddard Space Flight Center) ;
Sanders, Tanja G. M. (Thünen Institute of Forest Ecosystems) ;
Krüger, Inken (Thünen Institute of Forest Ecosystems) ;
Wang, Rong (Fudan University. Department of Environmental Science and Engineering) ;
Zeng, Ning (University of Maryland. Department of Atmospheric and Oceanic Science) ;
Tian, Hanqin (Auburn University. International Center for Climate and Global Change Research) ;
Vuichard, Nicolas (Centre National de la Recherche Scientifique. Laboratoire des Sciences du Climat et de l'Environnement) ;
Jain, Atul (University of Illinois. Department of Atmospheric Sciences) ;
Wiltshire, Andy (University of Exeter. College of Life and Environmental Sciences) ;
Haverd, Vanessa (CSIRO Oceans and Atmosphere (Australia)) ;
Goll, Daniel (Centre National de la Recherche Scientifique. Laboratoire des Sciences du Climat et de l'Environnement) ;
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals)
The enhanced vegetation productivity driven by increased concentrations of carbon dioxide (CO2) [i. e. , the CO2 fertilization effect (CFE)] sustains an important negative feedback on climate warming, but the temporal dynamics of CFE remain unclear. [...]
2020 - 10.1126/science.abb7772
Science, Vol. 370, Issue 6522 (December 2020) p. 1295-1300
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9.
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10 p, 667.8 KB |
Using patient values and preferences to inform the importance of health outcomes in practice guideline development following the GRADE approach
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Zhang, Yuan (McMaster University (Canadà)) ;
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Brozek, Jan (McMaster University (Canadà)) ;
Wiercioch, Wojtek (McMaster University (Canadà)) ;
Etxeandia-Ikobaltzeta, Itziar (McMaster University (Canadà)) ;
Akl, Elie A. (American University of Beirut) ;
Meerpohl, Joerg J. (Université Paris Descartes) ;
Alhazzani, Waleed (McMaster University (Canadà)) ;
Carrasco-Labra, Alonso (Universidad de Chile) ;
Morgan, Rebecca L. (McMaster University (Canadà)) ;
Mustafa, Reem A. (University of Missouri-Kansas City) ;
Riva, John J. (McMaster University (Canadà)) ;
Moore, Ainsley (McMaster University (Canadà)) ;
Yepes-Nuñez, Juan José (University of Antioquia) ;
Cuello-Garcia, Carlos (Tecnologico de Monterrey School of Medicine) ;
AlRayees, Zulfa (Ministry of Health) ;
Manja, Veena (University at Buffalo) ;
Falavigna, Maicon (Federal University of Rio Grande do Sul) ;
Neumann, Ignacio (Pontificia Universidad Católica de Chile) ;
Brignardello-Petersen, Romina (Universidad de Chile) ;
Santesso, Nancy (McMaster University (Canadà)) ;
Rochwerg, Bram (McMaster University (Canadà)) ;
Darzi, Andrea (American University of Beirut) ;
Rojas, Maria Ximena (Pontificia Universidad Javeriana) ;
Adi, Yaser (King Faisal Specialist Hospital and Research Centre) ;
Bollig, Claudia (University of Freiburg) ;
Waziry, Reem (University of New South Wales) ;
Schünemann, Holger J. (McMaster University (Canadà)) ;
Universitat Autònoma de Barcelona
There are diverse opinions and confusion about defining and including patient values and preferences (i. e. the importance people place on the health outcomes) in the guideline development processes. [...]
2017 - 10.1186/s12955-017-0621-0
Health and quality of life outcomes, Vol. 15 Núm. 1 (february 2017) , p. 52
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10.
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25 p, 927.1 KB |
Neuron numbers link innovativeness with both absolute and relative brain size
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Sol, Daniel (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Olkowicz, Seweryn (Charles University) ;
Sayol, Ferran (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Kocourek, Martin (Charles University) ;
Zhang, Yicheng (Charles University) ;
Marhounová, Lucie (Charles University) ;
Osadnik, Christin (University of Duisburg-Essen) ;
Corssmit, Eva (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Garcia-Porta, Joan (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Martin, Thomas E. (University of Montana) ;
Lefebvre Louis (McGill University) ;
Němec, Pavel (Charles University)
A longstanding issue in biology is whether the intelligence of animals can be predicted by absolute or relative brain size. However, progress has been hampered by an insufficient understanding of how neuron numbers shape internal brain organization and cognitive performance. [...]
2022 - 10.1038/s41559-022-01815-x
Nature ecology & evolution, Vol. 6 (July 2022) , p. 1381-1389
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