Resultats globals: 9 registres trobats en 0.02 segons.
Articles, 8 registres trobats
Documents de recerca, 1 registres trobats
Articles 8 registres trobats  
1.
15 p, 3.0 MB Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy / Piñol-Jurado, Patricia (Institut d'Investigació Biomèdica Sant Pau) ; Suarez-Calvet, Xavier (Institut d'Investigació Biomèdica Sant Pau) ; Fernández Simón, Esther (Institut d'Investigació Biomèdica Sant Pau) ; Gallardo, Eduard (Institut d'Investigació Biomèdica Sant Pau) ; de la Oliva, Natalia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Martínez-Muriana, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gómez-Gálvez, Pedro (Instituto de Biomedicina de Sevilla) ; Escudero, Luis M. (Instituto de Biomedicina de Sevilla) ; Pérez-Peiró, María (Institut d'Investigació Biomèdica Sant Pau) ; Wollin, Lutz (Immunology & Respiratory Diseases Research, Boehringer-Ingelheim, Biberach, Germany) ; de Luna Salva, Noemí (Institut d'Investigació Biomèdica Sant Pau) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Illa, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis and replacement of muscle by fibro-adipose tissue. [...]
2018 - 10.1038/s41419-018-0792-6
Cell death and disease, Vol. 9 (july 2018)  
2.
14 p, 836.7 KB Physically consistent scar tissue dynamics from scattered set of data : a novel computational approach to avoid the onset of the runge phenomenon / Sergi, Pier Nicola (Sant'Anna School of Advanced Studies. The BioRobotics Institute and Department of Excellence in Robotics and Artificial Intelligence) ; de la Oliva, Natalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Micera, Silvestro (Translational Neural Engineering Laboratory. Ecole Polytechnique Federale de Laussane)
The foreign body reaction is a complex biological process leading to the insulation of implanted artificial materials through a capsule of scar tissue. In particular, in chronic implanta-tions of neural electrodes, the prediction of the scar tissue evolution is crucial to assess the implant reliability over time. [...]
2021 - 10.3390/app11188568
Applied sciences (Basel), Vol. 11 Num. 18 (september 2021) , p. 8568  
3.
16 p, 872.2 KB Cholesterol Depletion Regulates Axonal Growth and Enhances Central and Peripheral Nerve Regeneration / Roselló-Busquets, Cristina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; de la Oliva, Natalia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Martínez-Mármol, Ramón (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Hernaiz-Llorens, Marc (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Pascual Sánchez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Muhaisen, Ashraf (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Del Valle, Jaume (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Soriano García, Eduardo (Institució Catalana de Recerca i Estudis Avançats)
Axonal growth during normal development and axonal regeneration rely on the action of many receptor signaling systems and complexes, most of them located in specialized raft membrane microdomains with a precise lipid composition. [...]
2019 - 10.3389/fncel.2019.00040
Frontiers in cellular neuroscience, Vol. 13 (February 2019) , art. 40  
4.
36 p, 1.9 MB Time course study of long-term biocompatibility and foreign body reaction to intraneural polyimide-based implants / de la Oliva, Natalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia)
The foreign body reaction (FBR) against an implanted device is characterized by the formation of a fibrotic tissue around the implant. In the case of interfaces for peripheral nerves, used to stimulate specific group of axons and to record different nerve signals, the FBR induces a matrix deposition around the implant creating a physical separation between nerve fibers and the interface that may reduce its functionality over time. [...]
2018 - 10.1002/jbm.a.36274
Journal of biomedical materials research : Part A, Vol. 106, Issue 3 (March 2018) , p. 746-757  
5.
26 p, 1.4 MB Dexamethasone Reduces the Foreign Body Reaction to Intraneural Electrode Implants in the Peripheral Nerve of the Rat / de la Oliva, Natalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia)
Intraneural electrodes must be in intimate contact with nerve fibers to have a proper function, but this interface is compromised due to the foreign body reaction (FBR). The FBR is characterized by a first inflammatory phase followed by a second anti-inflammatory and fibrotic phase, which results in the formation of a tissue capsule around the implant, causing physical separation between the active sites of the electrode and the nerve fibers. [...]
2018 - 10.1002/ar.23920
The anatomical record, Vol. 301, Issue 10 (October 2018) , p. 1722-1733  
6.
26 p, 1.2 MB Segregation of motor and sensory axons regenerating through bicompartmental tubes by combining extracellular matrix components with neurotrophic factors / Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia) ; Santos, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Delgado Martínez, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències) ; de la Oliva, Natalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giudetti, Guido (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ; Micera, Silvestro (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Segregation of regenerating motor and sensory axons may be a good strategy to improve selective functionality of regenerative interfaces to provide closed-loop commands. Provided that extracellular matrix components and neurotrophic factors exert guidance effects on different neuronal populations, we assessed in vivo the potential of separating sensory and motor axons regenerating in a bicompartmental Y-type tube, with each branch prefilled with an adequate combination of extracellular matrix and neurotrophic factors. [...]
2018 - 10.1002/term.2629
Journal of tissue engineering and regenerative medicine, Vol. 12, Issue 4 (April 2018) , p. e1991-e2000  
7.
12 p, 2.6 MB On the use of Parylene C polymer as substrate for peripheral nerve electrodes / de la Oliva, Natalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mueller, Matthias (Albert-Ludwig-University Freiburg. Department of Microsystems Engineering-IMTEK) ; Stieglitz, Thomas (Albert-Ludwig-University Freiburg. Department of Microsystems Engineering-IMTEK) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia)
Parylene C is a highly flexible polymer used in several biomedical implants. Since previous studies have reported valuable biocompatible and manufacturing characteristics for brain and intraneural implants, we tested its suitability as a substrate for peripheral nerve electrodes. [...]
2018 - 10.1038/s41598-018-24502-z
Scientific reports, Vol. 8 (April 2018) , art. 5965  
8.
9 p, 973.4 KB Long-term functionality of transversal intraneural electrodes is improved by dexamethasone treatment / de la Oliva, Natalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Delgado Martínez, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mueller, Matthias (Albert Ludwig University Freiburg. Laboratory for Biomedical Microtechnology) ; Stieglitz, Thomas (Albert Ludwig University Freiburg. Laboratory for Biomedical Microtechnology) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Institut Català de Nanociència i Nanotecnologia (ICN2)
Neuroprostheses aimed to restore lost functions after a limb amputation are based on the interaction with the nervous system by means of neural interfaces. Among the different designs, intraneural electrodes implanted in peripheral nerves represent a good strategy to stimulate nerve fibers to send sensory feedback and to record nerve signals to control the prosthetic limb. [...]
2019 - 10.1109/TNSRE.2019.2897256
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2019  

Documents de recerca 1 registres trobats  
1.
183 p, 7.3 MB Biological response to implanted intraneural electrodes / de la Oliva, Natalia ; Navarro, X. (Xavier), (Xavier) dir. ; Del Valle, Jaume, dir. ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
La reacció de cos estrany (FBR, per les sigles en anglès) és una resposta del sistema immunitari envers qualsevol dispositiu implantat al cos. Diversos estudis han demostrat que aquesta resposta consta d'una primera fase inflamatòria seguida d'una fase de remodelació del teixit, que resulta en la encapsulació del cos estrany. [...]
The foreign body reaction (FBR) is an immune-mediated response to any device implanted in the body. Several studies have shown that it is characterized by a first inflammatory phase followed by a tissue remodeling phase, which results in the encapsulation of the foreign body. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2018.  

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