Flexible geoadditive survival analysis of non-Hodgkin lymphoma in Peru
Flores, Claudio (Universitat Politècnica de Catalunya. Departament de Estadística)
Rodríguez-Girondo, Mar (Universidade de Vigo)
Cadarso-Suárez, Carmen (Universidade de Santiago de Compostela. Departamento de Estatística, Análise Matemática e Optimización)
Kneib, Thomas (Georg August University. Department of Economics)
Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya. Departament de Estadística)
Casanova, Luis (Instituto Nacional de Enfermedades Neoplásicas (Lima, Perú))

Date:	2012
Abstract:	Knowledge of prognostic factors is an important task for the clinical management of Non Hodgkin Lymphoma (NHL). In this work, we study the variables affecting survival of NHL in Peru by means of geoadditive Cox-type structured hazard regression models while accounting for potential spatial correlations in the survival times. We identified eight covariates with significant effect for overall survival. Some of them are widely known such as age, performance status, clinical stage and lactic dehydrogenase, but we also identified hemoglobin, leukocytes and lymphocytes as covariates with a significant effect on the overall survival of patients with NHL. Besides, the effect of continuous covariates is clearly nonlinear and hence impossible to detect with the classical Cox method. Although the spatial component does not show a significant effect, the results show a trend of low risk in certain areas.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Non-Hodgkin lymphoma ; Structured regression models ; Survival analysis
Published in:	SORT : statistics and operations research transactions, Vol. 36, Núm. 2 (juliol-desembre 2012) , p. 221-230, ISSN 2013-8830

Adreça alternativa: https://raco.cat/index.php/SORT/article/view/260683

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