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Latest additions:
2024-03-01
09:28
12 p, 4.8 MB Down syndrome and leukemia : from basic mechanisms to clinical advances / Baruchel, André (Hôpital Universitaire Robert Debré, Paris, France) ; Bourquin, Jean Pierre (University Children's Hospital, Zurich, Switzerland) ; Crispino, John (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica)) ; Cuartero, Sergi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Hasle, Henrik (Aarhus University Hospital, Denmark) ; Hitzler, Johann (The Hospital for Sick Children, Toronto, Canada) ; Klusmann, Jan Henning (Goethe University Frankfurt, Germany) ; Izraeli, Shai (Tel Aviv University, Tel Aviv, Israel) ; Lane, Andrew A. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Malinge, Sebastien (Cancer Centre, Perth, Western Australia) ; Rabin, Karen R. (University of Oxford, UK) ; Roberts, Irene (University of Oxford, UK) ; Ryeom, Sandra (Columbia University Irving Medical Center, New York, USA) ; Tasian, Sarah K. (University of Pennsylvania Perelman School of Medicine, Philadelphia, USA) ; Wagenblast, Elvin (Icahn School of Medicine at Mount Sinai, New York, USA)
Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades. [...]
2023 - 10.3324/haematol.2023.283225
Haematologica, Vol. 108 Núm. 10 (october 2023) , p. 2570-2581  
2024-03-01
09:28
27 p, 3.9 MB The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks / Pereira, Quélita Cristina (Sao Francisco University Medical School, Brazil) ; dos Santos, Tanila Wood (Sao Francisco University Medical School, Brazil) ; Fortunato, I.M. (Sao Francisco University Medical School, Brazil) ; Ribeiro, M.L. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. [...]
2023 - 10.3390/ijms24065508
International journal of molecular sciences, Vol. 24 Núm. 6 (march 2023)  
2024-03-01
09:28
12 p, 16.0 MB Gastric metaplasia as a precursor of nonconventional dysplasia in inflammatory bowel disease / Musulén, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Gené, Míriam (Hospital Universitari Joan XXIII) ; Cuatrecasas, Míriam (Hospital Clínic i Provincial de Barcelona) ; Amat, Irene (Complejo Hospitalario de Navarra) ; Veiga, Jesús Alberto (Complejo Hospitalario Universitario de Ferrol) ; Fernández-Aceñero, María Jesús (Hospital Clínico San Carlos) ; Chimisana, Victòria Fusté (Hospital de La Santa Creu I Sant Pau) ; Tarragona, Jordi (Hospital Universitari Arnau de Vilanova) ; Jurado, Ismael (Consorci Sanitari de Terrassa) ; Fernández-Victoria, Rebeca (Hospital Álvaro Cunqueiro) ; Martínez-Ciarpaglini, Carolina (Hospital Clínico Universitario de Valencia) ; Alenda González, Cristina (Hospital General Universitario Dr. Balmis) ; Zac, Carlos (Hospital Universitari I Politècnic La Fe) ; Fernández-Figueras, María Teresa (Universitat Internacional de Catalunya (UIC)) ; Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Gastric metaplasia in colonic mucosa with inflammatory bowel disease (IBD) develops as an adaptation mechanism. The association between gastric metaplasia and nonconventional and/or conventional dysplasia as precursors of colitis-associated colorectal cancer is unknown. [...]
2024 - 10.1016/j.humpath.2023.11.011
Human Pathology, Vol. 143 (january 2024) , p. 50-61  
2024-03-01
09:28
6 p, 870.5 KB Characterization of a cohort of metastatic lung cancer patients harboring KRAS mutations treated with immunotherapy : differences according to KRAS G12C vs. non-G12C / Notario, Lucía (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cucurull, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cerdà, Gabriela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sanz, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Muñoz-Mármol, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Hernández, Ainhoa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Domènech, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sánchez-Céspedes, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Costa, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mate, Jose Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Esteve, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Saigí, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Approximately 20% of lung adenocarcinomas harbor activating mutations at KRAS, an oncogene with the ability to alter the tumor immune microenvironment. In this retrospective study, we examined 103 patients with KRAS-mutant lung adenocarcinoma who were treated with immunotherapy-based regimens and we evaluated the clinical outcomes according to PD-L1 expression and the type of KRAS mutation. [...]
2023 - 10.3389/fonc.2023.1239000
Frontiers in Oncology, Vol. 13 (october 2023)  
2024-03-01
09:28
Maternal Stress, Anxiety, Well-Being, and Sleep Quality in Pregnant Women throughout Gestation / Pascal, Rosalia (Institut de Recerca Sant Joan de Déu) ; Casas, Irene (Institut D'investigacions Biomèdiques August Pi Sunyer) ; Genero, Mariona (Institut de Recerca Sant Joan de Déu) ; Nakaki, Ayako (Institut D'investigacions Biomèdiques August Pi Sunyer) ; Youssef, Lina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Larroya, Marta (Institut D'investigacions Biomèdiques August Pi Sunyer) ; Benitez, Leticia (Institut D'investigacions Biomèdiques August Pi Sunyer) ; Gomez, Yvan (Hospital Sant Joan de Déu and Hospital Clínic) ; Martínez-Àran, Anabel (Universitat de Barcelona) ; Morilla, Ivette (Universitat de Barcelona) ; Oller-Guzmán, Teresa M. (Instituto esMindfulness) ; Martín-Asuero, Andrés (Instituto esMindfulness) ; Vieta, Eduard (Department of Psychiatry and Psychology. University of Barcelona) ; Crispi, Fàtima (Center for Biomedical Network Research on Rare Diseases) ; Gratacos, Eduard (Center for Biomedical Network Research on Rare Diseases) ; Gomez-Roig, María Dolores (Institut de Recerca Sant Joan de Déu) ; Crovetto, Francesca (Institut de Recerca Sant Joan de Déu) ; Universitat Autònoma de Barcelona
Background: Maternal stress, anxiety, well-being, and sleep quality during pregnancy have been described as influencing factors during pregnancy. Aim: We aimed to describe maternal stress, anxiety, well-being, and sleep quality in pregnant women throughout gestation and their related factors. [...]
2023 - 10.3390/jcm12237333
Journal of clinical medicine, Vol. 12 Núm. 23 (december 2023) , p. 7333  
2024-03-01
09:28
Diet quality and nutrient density in pregnant women according to adherence to Mediterranean diet / Castro-Barquero, Sara (Universitat de Barcelona) ; Larroya, Marta (Hospital Clínic and Hospital Sant Joan de Déu) ; Crispi, Fátima (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Estruch, Ramon (Universitat de Barcelona) ; Nakaki, Ayako (Institut de Recerca August Pi Sunyer) ; Paules, Cristina (Instituto de Salud Carlos III) ; Ruiz-León, Ana María (Mediterranean Diet Foundation) ; Sacanella, Emilio (Department of Internal Medicine. Universitat de Barcelona) ; Freitas, Tania (Hospital Clínic and Hospital Sant Joan de Déu) ; Youssef, Lina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Benitez, Leticia (Institut de Recerca August Pi Sunyer) ; Casas, Irene (Institut de Recerca Sant Joan de Deu) ; Genero, Mariona (Institut de Recerca Sant Joan de Deu) ; Gomez, Sílvia (Fetal Medicine Research Center. BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu). Universitat de Barcelona) ; Casanovas-Garriga, Francesc (Universitat de Barcelona) ; Gratacós, Eduard (Institut de Recerca Sant Joan de Deu) ; Casas, Rosa (Universitat de Barcelona) ; Crovetto, Francesca (Instituto de Salud Carlos III) ; Universitat Autònoma de Barcelona
Background and aims: The dietary pattern followed during pregnancy, specifically healthy dietary patterns such as the Mediterranean diet, is a key factor in the mother's and the offspring's health. Pregnant women dietary intake is not enough to cover the micronutrient requirements of pregnancy, and higher adherence to the Mediterranean diet may improve dietary quality and nutritional density. [...]
2023 - 10.3389/fpubh.2023.1144942
Frontiers in Public Health, Vol. 11 (2023) , p. 1144942  
2024-03-01
09:28
Plain language summary of the MajesTEC-1 study of teclistamab for the treatment of people with relapsed or refractory multiple myeloma / Moreau, Philippe (University Hospital Hôtel-Dieu) ; Van De Donk, Niels WCJ (Department of Hematology. Amsterdam University Medical Center) ; Nahi, Hareth (Karolinska University Hospital and Karolinska Institutet (Suecia)) ; Oriol, Albert (Institut Català d'Oncologia & Institut Josep Carreras. Hospital Germans Trias i Pujol) ; Nooka, Ajay K (Winship Cancer Institute. Emory University) ; Martin, Thomas (University of California San Francisco) ; Rosinol, Laura (Hospital Clínic) ; Karlin, Lionel (Centre Hospitalier Lyon Sud) ; Benboubker, Lotfi (Hôpital Bretonneau) ; Mateos, Maria-Victoria (University Hospital de Salamanca) ; Popat, Rakesh (Clinical Research Facility. National Institute for Health Research University College London Hospitals) ; Martínez-López, Joaquín (Hematological Malignancies Clinical Research Unit. Hospital 12 de Octubre Universidad Complutense. Centro Nacional de Investigaciones Oncológicas. Ciberonc) ; Sidana, Surbhi (Stanford University of Medicine) ; Delforge, Michele (University of Leuven) ; Pei, Lixia (Janssen Research & Development) ; Trancucci, Danielle (Janssen Research & Development) ; Olyslager, Yunsi (Janssen Research & Development) ; Uhlar, Clarissa (Janssen Research & Development) ; Stephenson, Tara (Janssen Research & Development) ; Rampelbergh, Rian Van (Janssen Research & Development) ; Banerjee, Arnob (Janssen Research & Development) ; Kobos, Rachel (Janssen Research & Development) ; Usmani, Saad Z (Levine Cancer Institute-Atrium Health)
What is this summary about? This is a summary of a phase 1-2 clinical trial called MajesTEC-1. This trial tested the cancer drug teclistamab in people with relapsed or refractory multiple myeloma, a cancer that forms in a certain type of white blood cells known as plasma cells. [...]
2023 - 10.2217/fon-2023-0171
Future oncology (London, England), Vol. 19 Núm. 12 (january 2023) , p. 811-818  
2024-03-01
09:28
SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations / Banerjee, Kuheli (Heidelberg University) ; Lin, Yanzhu (EHeidelberg University) ; Gahn, Johannes (Heidelberg University) ; Cordero, Julio (German Centre for Cardiovascular Research) ; Gupta, Purnima (Heidelberg University) ; Mohamed, Islam (Heidelberg University) ; Graupera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Dobreva, Gergana (German Centre for Cardiovascular Research) ; Schwartz, Martin A. (Yale School of Medicine) ; Ola, Roxana (Heidelberg University)
Vascular networks form, remodel, and mature under the influence of both fluid shear stress (FSS) and soluble factors. Physiological FSS promotes and maintains vascular stability via synergy with bone morphogenic proteins 9 and 10 (BMP9 and BMP10). [...]
2023 - 10.1172/JCI168352
The journal of clinical investigation, Vol. 133 Núm. 18 (15 2023) , p. e168352  
2024-03-01
09:28
Head and neck cancers survival in Europe, Taiwan, and Japan : results from RARECAREnet Asia based on a privacy-preserving federated infrastructure / Botta, Laura (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ; Matsuda, Tomohiro (Insititute of Cancer Control. National Cancer Center (Japò)) ; Charvat, Hadrien (National Cancer Center (Japò)) ; Chiang, Chung-Ju (Taiwan Cancer Registry Center. Institute of Epidemiology and Preventive Medicine) ; Lee, Wen-Chung (Taiwan Cancer Registry Center) ; van Gestel, Anna Jacoba (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ; Martin, Frank (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ; Geleijnse, Gijs (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ; Cellamare, Mattheo (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ; Bonfarnuzzo, Simone (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ; Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Guevara, Marcela (Epidemiology and Public Health Area. Navarra Institute for Health Research) ; Mousavi, Mohsen (East Switzerland Cancer Registry) ; Craig, Stefano (Queen's University Belfast) ; Rodrigues, Jessica (Porto Comprehensive Cancer Centre (Portugal)) ; Rubió-Casadevall, Jordi (Biomedical Research Institute) ; Licitra, Lisa (Department of Oncology and Hemato-Oncology. University of Milan) ; Cavalieri, Stephanie (Department of Oncology and Hemato-Oncology. University of Milan) ; Resteghini, Carlo (Head and Neck Medical Oncology Department. Fondazione IRCCS Istituto Nazionale dei Tumori) ; Gatta, Gemma (Evaluative Epidemiology Unit. Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ; Trama, Annalisa (Evaluative Epidemiology Unit. Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori)
Background: The head and neck cancers (HNCs) incidence differs between Europe and East Asia. Our objective was to determine whether survival of HNC also differs between European and Asian countries. [...]
2023 - 10.3389/fonc.2023.1219111
Frontiers in Oncology, Vol. 13 (2023) , p. 1219111  
2024-03-01
09:28
Reduced 8-Gray Compared to Standard 12-Gray Total Body Irradiation for Allogeneic Transplantation in First Remission Acute Lymphoblastic Leukemia : A Study of the Acute Leukemia Working Party of the EBMT / Spyridonidis, Alexandros (University of Patras) ; Labopin, Myriam (Sorbonne University) ; Savani, Bipin (Vanderbilt University Medical Center) ; Giebel, Sebastian (Maria Sklodowska-Curie National Research Institute of Oncology) ; Bug, Gesine (Department of Medicine II. Goethe-University) ; Schönland, Stefan (Medical Department V. University Hospital Heidelberg) ; Kröger, Nicolaus (Department of Stem Cell Transplantation. University Medical Center) ; Stelljes, Matthias (Department of Hematology/Oncology. University of Muenster) ; Schroeder, Thomas (Department of Bone Marrow Transplantation. University Hospital) ; Mcdonald, Andrew (Netcare Pretoria East Hospital) ; Blau, Igor-Wolfgang (Charité - Universitätsmedizin Berlin) ; Bornhäuser, Martin (University Hospital. TU Dresden) ; Rovira, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bethge, Wolfgang (Department of Hematology & Oncology. University Hospital Tuebingen.) ; Neubauer, Andreas (Philipps Universitaet Marburg) ; Ganser, Arnold (Hannover Medical School) ; Bourhis, Jean Henri (Gustave Roussy Cancer Campus BMT. Department of Hematology) ; Edinger, Matthias (Department of Hematology and Oncology. University Regensburg) ; Lioure, Bruno (Hematology. Stem Cell Transplant Unit. ICANS) ; Wulf, Gerald (University Medicine Goettingen) ; Schäfer-Eckart, Kerstin (Klinikum Nuernberg. 5. Medizinische Klinik. BMT-Unit) ; Arat, Mutlu (Demiroglu Bilim Univ. Istanbul Florence Nightingale Hospital) ; Peric, Zinaida (University Hospital Centre) ; Schmid, Christoph (Universitatsklinikum Augsburg. Section Stem Cell Transplantation. Augsburg University and Medical Faculty) ; Bazarbachi, Ali (Bone Marrow Transplantation Program. Department of Internal Medicine. American University of Beirut-Medical Center) ; Ciceri, Fabio (Ospedale San Raffaele) ; Nagler, Arnon (Hematology Division. Chaim Sheba Medical Center) ; Mohty, Mohamad (Sorbonne University)
In this registry-based study, we compared outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) in adult patients with acute lymphoblastic leukemia (ALL) transplanted in first complete remission (CR-1), following conditioning with total body irradiation (TBI) at a standard 12-Gray or at a lower 8-Gray total dose. [...]
2023 - 10.1097/HS9.0000000000000812
HemaSphere, Vol. 7 Núm. 1 (september 2023) , p. e812  
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