Possible role of WDR3 gene on genome stability in thyroid cancer patients
García Quispes, Wilser Andrés (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Galofré, Pere (Hospital Universitari Vall d'Hebron)
Biarnés, Josefina (Hospital Universitari de Girona Doctor Josep Trueta)
Castell-Conesa, Joan (Hospital Universitari Vall d'Hebron)
Velázquez Henar, Antonia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Date:	2012
Abstract:	The role of the WDR3 gene on genomic instability has been evaluated in a group of 115 differentiated thyroid cancer (DTC) patients. Genomic instability has been measured according to the response of peripheral blood lymphocytes to ionizing radiation (0. 5 Gy). The response has been measured with the micronucleus (MN) test evaluating the frequency of binucleated cells with MN (BNMN), both before and after the irradiation. No differences between genotypes, for the BNMN frequencies previous the irradiation, were observed. Nevertheless significant decreases in DNA damage after irradiation were observed in individuals carrying the variant alleles for each of the three genotyped SNPs: rs3754127 [−8. 85 (−15. 01 to −2. 70), P<0. 01]; rs3765501 [−8. 98 (−15. 61 to −2. 36), P<0. 01]; rs4658973 [−8. 70 (−14. 94 to −2. 46), P<0. 01]. These values correspond to those obtained assuming a dominant model. This study shows for the first time that WDR3 can modulate genome stability.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; Versió publicada
Subject:	Tiroide ; Càncer ; Genoma humà ; Differentiated thyroid cancer ; WDR3 gene
Published in:	PloS one, Vol. 7, Issue 9 (September 2012) , p. e44288, ISSN 1932-6203

DOI: 10.1371/journal.pone.0044288
PMID: 23049746

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