Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depressive-like behaviour in the rat
Castro, Jorge E. (École Polytechnique Fédérale de Lausanne (Suïssa). Brain Mind Institute)
Varea, Emilio (École Polytechnique Fédérale de Lausanne (Suïssa). Brain Mind Institute)
Márquez Vega, Cristina (École Polytechnique Fédérale de Lausanne (Suïssa). Brain Mind Institute)
Cordero, María Isabel (École Polytechnique Fédérale de Lausanne (Suïssa). Brain Mind Institute)
Poirier, Guillaume (École Polytechnique Fédérale de Lausanne (Suïssa). Brain Mind Institute)
Sandi, Carmen (École Polytechnique Fédérale de Lausanne (Suïssa). Brain Mind Institute)

Data:	2010
Resum:	The stimulation of adult hippocampal neurogenesis by antidepressants has been associated with multiple molecular pathways, but the potential influence exerted by other brain areas has received much less attention. The basolateral complex of the amygdala (BLA), a region involved in anxiety and a site of action of antidepressants, has been implicated in both basal and stress-induced changes in neural plasticity in the dentate gyrus. We investigated here whether the BLA modulates the effects of the SSRI antidepressant fluoxetine on hippocampal cell proliferation and survival in relation to a behavioral index of depression-like behavior (forced swim test). We used a lesion approach targeting the BLA along with a chronic treatment with fluoxetine, and monitored basal anxiety levels given the important role of this behavioral trait in the progress of depression. Chronic fluoxetine treatment had a positive effect on hippocampal cell survival only when the BLA was lesioned. Anxiety was related to hippocampal cell survival in opposite ways in sham- and BLA-lesioned animals (i. e. , negatively in sham- and positively in BLA-lesioned animals). Both BLA lesions and low anxiety were critical factors to enable a negative relationship between cell proliferation and depression-like behavior. Therefore, our study highlights a role for the amygdala on fluoxetine-stimulated cell survival and on the establishment of a link between cell proliferation and depression-like behavior. It also reveals an important modulatory role for anxiety on cell proliferation involving both BLA-dependent and -independent mechanisms. Our findings underscore the amygdala as a potential target to modulate antidepressants' action in hippocampal neurogenesis and in their link to depression-like behaviors.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; Versió publicada
Matèria:	Estrès ; Depression ; Basolateral complex of the amygdale ; BLA
Publicat a:	PloS one, Vol. 5, Issue 1 (January 2010) , p. e8618, ISSN 1932-6203

DOI: 10.1371/journal.pone.0008618
PMID: 20062812

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