Screening for Coping Style Increases the Power of Gene Expression Studies
Mackenzie, Simon (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Ribas Cabezas, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Pilarczyk, Maciej (Polska Akademia Nauk, Zakład Ichtiobiologii i Gospodarki Rybackiej, Zaborze)
Morera, Davinia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Kadri, Sunil (University of Glasgow)
Huntingford, Felicity A. (University of Glasgow)

Date:	2009
Abstract:	Individuals of many vertebrate species show different stress coping styles and these have a striking influence on how gene expression shifts in response to a variety of challenges. This is clearly illustrated by a study in which common carp displaying behavioural predictors of different coping styles (characterised by a proactive, adrenaline-based or a reactive, cortisol-based response) were subjected to inflammatory challenge and specific gene transcripts measured in individual brains. Proactive and reactive fish differed in baseline gene expression and also showed diametrically opposite responses to the challenge for 80% of the genes investigated. Incorporating coping style as an explanatory variable can account for some the unexplained variation that is common in gene expression studies, can uncover important effects that would otherwise have passed unnoticed and greatly enhances the interpretive value of gene expression data.
Note:	Altres ajuts: S.M. and co-workers are partly funded by the MICInn, Spain(Consolider-Ingenio 2010). This work was partly funded within the EU-funded project, Seafood Plus
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 4, Issue 4 (April 2009) , art. e5314, ISSN 1932-6203

DOI: 10.1371/journal.pone.0005314
PMID: 19390591

5 p, 149.8 KB

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