Optimization, evaluation, and comparison of standard algorithms for image reconstruction with the VIP-PET
Mikhaylova, Ekaterina (Institut de Física d'Altes Energies)
Kolstein, Machiel (Institut de Física d'Altes Energies)
De Lorenzo, Gianluca (Institut de Física d'Altes Energies)
Chmeissani, Mokhtar (Institut de Física d'Altes Energies)

Date:	2014
Abstract:	A novel positron emission tomography (PET) scanner design based on a room-temperature pixelated CdTe solid-state detector is being developed within the framework of the Voxel Imaging PET (VIP) Pathfinder project []. The simulation results show a great potential of the VIP to produce high-resolution images even in extremely challenging conditions such as the screening of a human head []. With unprecedented high channel density (450 channels/cm 3) image reconstruction is a challenge. Therefore optimization is needed to find the best algorithm in order to exploit correctly the promising detector potential. The following reconstruction algorithms are evaluated: 2-D Filtered Backprojection (FBP), Ordered Subset Expectation Maximization (OSEM), List-Mode OSEM (LM-OSEM), and the Origin Ensemble (OE) algorithm. The evaluation is based on the comparison of a true image phantom with a set of reconstructed images obtained by each algorithm. This is achieved by calculation of image quality merit parameters such as the bias, the variance and the mean square error (MSE). A systematic optimization of each algorithm is performed by varying the reconstruction parameters, such as the cutoff frequency of the noise filters and the number of iterations. The region of interest (ROI) analysis of the reconstructed phantom is also performed for each algorithm and the results are compared. Additionally, the performance of the image reconstruction methods is compared by calculating the modulation transfer function (MTF). The reconstruction time is also taken into account to choose the optimal algorithm. The analysis is based on GAMOS [] simulation including the expected CdTe and electronic specifics.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Medical-image reconstruction methods and algorithms ; Computer-aided software ; Gamma camera ; SPECT ; PET PET/CT ; Coronary CT angiography (CTA)
Published in:	Journal of instrumentation, Vol. 9 (july 2014) , ISSN 1748-0221

DOI: 10.1088/1748-0221/9/07/C07004
PMID: 25018777

14 p, 803.5 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Institut de Física d’Altes Energies (IFAE)
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