Off-label use of rituximab for systemic lupus erythematosus in Europe
Rydén-Aulin, Monica (Karolinska University Hospital and Karolinska Institutet (Suècia))
Boumpas, Dimitrios (Kapodestrian University of Athens)
Bultink, Irene (Amsterdam Rheumatology and Immunology Center)
Callejas Rubio, Jose Luis (Hospital Universitario San Cecilio (Granada))
Caminal-Montero, Luis (Hospital Universitario Central de Asturias)
Castro, Antoni (Hospital Universitari Sant Joan de Reus (Tarragona))
Colodro Ruiz, Agustín
Doria, Andrea (University of Padova)
Dörner, Thomas (Charite Universitaetsmedizin Berlin)
González-Echávarri, Cristina (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Gremese, Elisa (Institute of Rheumatology and Affine Sciences (IRSA), Catholic University of the Sacred Heart)
Houssiau, Frederic A. (Université Catholique de Louvain)
Huizinga, Tom
Inanç, Murat (Istanbul University)
Isenberg, David (University College London)
Iuliano, Annamaria (San Camillo Forlanini Hospital)
Jacobsen, Søren (University of Copenhagen)
Jimenéz-Alonso, Juan (Hospital Universitario Virgen de las Nieves (Granada))
Kovács, Lászlo (University of Szeged. Albert Szent-Györgyi Health Centre)
Mariette, Xavier (Université Paris-Sud)
Mosca, Marta (Rheumatology Unit, Pisa)
Nived, Ola (Skåne University Hospital (Suècia))
Oristrell, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina)
Ramos-Casals, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Rascón, Javier
Ruiz-Irastorza, Guillermo (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Sáez-Comet, Luis (Hospital Universitario Miguel Servet (Saragossa))
Salvador Cervelló, Gonzalo (Hospital Universitari i Politècnic La Fe (València))
Sebastiani, Gian Domenico (Ospedale San Camillo)
Squatrito, Danilo (University of Florence)
Szücs, Gabriella (Institute of Medicine, University of Debrecen)
Voskuyl, Alexandre (Amsterdam Rheumatology and Immunology Center (ARC))
van Vollenhoven, Ronald (Amsterdam Rheumatology and Immunology Center ARC)

Fecha:	2016
Resumen:	Rituximab (RTX) is a biological treatment used off-label in patients with systemic lupus erythematosus (SLE). This survey aimed to investigate the off-label use of RTX in Europe and compare the characteristics of patients receiving RTX with those receiving conventional therapy. Data on patients with SLE receiving RTX were taken from the International Registry for Biologics in SLE retrospective registry and complemented with data on patients with SLE treated with conventional therapy. For nationwide estimates of RTX use in patients with SLE, investigators were asked to provide data through case report forms (CRFs). Countries for which no data were submitted through CRFs, published literature and/or personal communication were used, and for European countries where no data were available, estimates were made on the assumption of similarities with neighbouring countries. The estimated off-label use of RTX in Europe was 0. 5%-1. 5% of all patients with SLE. In comparison with patients with SLE on conventional therapy, patients treated with RTX had longer disease duration, higher disease activity and were more often treated with immunosuppressives. The most frequent organ manifestations for which either RTX or conventional therapy was initiated were lupus nephritis followed by musculoskeletal and haematological. The reason for treatment was, besides disease control, corticosteroid-sparing for patients treated with conventional therapy. RTX use for SLE in Europe is restrictive and appears to be used as a last resort in patients for whom other reasonable options have been exhausted.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució i la comunicació pública de l'obra, sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Systemic Lupus Erythematosus ; DMARDs (biologic) ; Lupus Nephritis
Publicado en:	Lupus Science & Medicine, Vol. 3 (september 2016) , ISSN 2053-8790

DOI: 10.1136/lupus-2016-000163
PMID: 27651920

8 p, 676.9 KB

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