Deciphering hIAPP : a novel way to cure diabetes
Ruiz López, Iñigo
Pallarès i Goitiz, Irantzu, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Universitat Autònoma de Barcelona. Facultat de Biociències

Date:	2019-05-29
Abstract:	Human islet amyloid polypeptide (hIAPP) is produced by pancreatic β-cells and is involved in type-II diabetes mellitus (T2DM) pathogenesis. In T2DM, the loss of pancreatic β-cell mass is accompanied by the accumulation of amyloid deposits of hIAPP. The relationship between amyloidosis, cell-death and disease progression is extremely complex. My work discusses the evidence supporting the role of oligomers as drivers of toxicity, suggests a model to understand IAPP interaction with membranes and proposes unexplored therapeutic approaches.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Studies:	Biotecnologia [2500253]
Study plan:	Grau en Biotecnologia [815]
Document:	Treball final de grau
Subject:	Hiapp ; T2DM ; Beta-cells ; Diabetes ; Oligomers ; Membrane ; Membrane-disruption ; Amyloid ; Aggregation ; Therapy ; Protein misfolding disease

1 p, 10.8 MB

The record appears in these collections:
Research literature > Bachelor's degree final project > Biosciences Faculty