| Fecha: |
2019 |
| Resumen: |
Chronic neuroinflammation is an important component in multiple sclerosis (MS) progression, since the persistent microglial and astrocytic activation promotes neurodegeneration and a consequent neurological disability. Although the MS etiology remains still unclear, gut dysbiosis has emerged as a potential pathogenic factor. As a consequence of the imbalance in microbial populations, a reduction of circulating short-chain fatty acids (SFCAs) or tryptophan metabolites has been identified in MS patients. However, little is known about its effects on the activity of microglia and astrocytes and the consequences on neuroinflammation. Therefore, the objectives of this review are: 1) To describe the profile of gut microbiota in MS patients; 2) To determine the role of CNS-resident cells in MS pathogenesis; 3) To analyse how the reduction of SCFAs and tryptophan metabolites affects microglia and astrocytes in MS progression. |
| Derechos: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Lengua: |
Anglès |
| Titulación: |
Ciències Biomèdiques [2501230] |
| Plan de estudios: |
Grau en Ciències Biomèdiques [832] |
| Documento: |
Treball final de grau ; Text |
| Materia: |
Microbiota ;
Gut dybiosis ;
Multiple sclerosis ;
Microglia ;
Astrocytes ;
Tryptophan metabolites ;
SCFAs |
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