Retinal microperimetry : a useful tool for detecting insulin resistance-related cognitive impairment in morbid obesity
Ciudin, Andreea (Hospital Universitari Vall d'Hebron)
Ortiz-Zúñiga, Ángel Michael (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Fidilio, Enzamaria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Romero, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Sanchez, Marta (Hospital Universitari Vall d'Hebron)
Comas Martínez, Marta (Hospital Universitari Vall d'Hebron)
González López, Óscar 1969- (Hospital Universitari Vall d'Hebron)
Vilallonga, Ramon (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina)
Hernández, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina)
Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2019
Abstract:	Background: There is clear association between type 2 diabetes (T2D) and cognitive decline. Retinal microperimetry is a useful tool for detecting cognitive impairment in T2D. Morbid obesity (MO) has been associated with cognitive impairment. Insulin resistance (IR) seems a major determinant, but the data are unclear. The aim of this study was to evaluate the cognitive impairment in MO as well as the utility of retinal microperimetry in identifying these alterations. Methods: In total, 50 consecutive patients with MO were matched by age and gender with 30 healthy controls. All patients underwent cognitive evaluation (Montreal Cognitive Assessment Test-MoCA) and retinal microperimetry, using MAIA microperimeter 3rd generation. Retinal sensitivity and gaze fixation parameters were used for the evaluation of the analysis. Results: MO patients showed a significantly lower neurocognitive performance than the controls: MoCA score 24. 94 ± 2. 74 vs. 28. 95 ± 1. 05, p < 0. 001. Cognitive function inversely correlated with the HOMA-IR (r = −0. 402, p = 0. 007). The AUROC for cognitive impairment using microperimetry was 0. 807, CI 95% (0. 592-0. 947), p = 0. 017. Conclusions: (1) Systemic insulin resistance is a major underlying mechanism accounting for the higher prevalence of cognitive impairment detected in young MO subjects. (2) Retinal microperimetry is a useful tool for identifying MO patients with cognitive impairment.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Morbid obesity ; Cognitive impairment ; Retinal microperimetry ; Insulin resistance
Published in:	Journal of clinical medicine, Vol. 8 (2019) , ISSN 2077-0383

DOI: 10.3390/jcm8122181
PMID: 31835729

11 p, 1.3 MB

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