Central sensitization in knee osteoarthritis and fibromyalgia : beyond depression and anxiety
López Ruiz, Marina (Clínica Sant Jordi)
Losilla Vidal, Josep Maria (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Monfort, Jordi (Hospital del Mar (Barcelona, Catalunya))
Portell Vidal, Mariona (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Gutiérrez Rosado, Teresa (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Poca Dias, Violant (Institut Ferran de Reumatologia (Barcelona, Catalunya))
García Fructuoso, Ferran (Institut Ferran de Reumatologia (Barcelona, Catalunya))
Llorente, Jone (Hospital del Mar (Barcelona, Catalunya))
Garcia Fontanals, Alba (Benito Menni Complex Assistencial en Salut Mental (Sant Boi de Llobregat, Catalunya))
Deus Yela, Juan (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)

Date:	2019
Abstract:	Objectives: To determine the psychopathological profile of patients with central sensitization (CS) in a sample of knee osteoarthritis, with and without CS, and fibromyalgia, and to compare their psychopathological profiles. Methods The final sample consists of 19 patients with osteoarthritis and CS (mean 66. 37 years ± 8. 77), 41 osteoarthritis patients without CS (mean 66. 8 ± 7. 39 years), 47 fibromyalgia patients (mean 46. 47 years ± 7. 92) and 26 control subjects (mean 51. 56 years ± 11. 41). The psychopathological profile was evaluated with the Millon Multiaxial Clinical Inventory. Results The average score of MCMI-III reflect higher scores in the fibromyalgia and osteoarthritis-CS groups. Patients with osteoarthritis-CS are more likely to report larger scores in Borderline and Major Depression scales. Fibromyalgia patients are more likely to report more increased scores in Somatoform and Major Depression, versus osteoarthritis-CS group. Fibromyalgia patients versus osteoarthritis without CS are more likely to report higher scores in Schizoid, Depression, Histrionic, Sadistic, Borderline, Somatoform, Posttraumatic Stress Disorder and Major Depression scales. Discussion Patients with CS have less differences in their psychopathological profiles as well as in both osteoarthritis groups and greatest differences are obtained between the fibromyalgia and osteoarthritis without CS, so perhaps presence of CS is the key to differentiate those groups and not chronic pain. An exhaustive assessment brings more accurate psychopathological profiles, thus better psychological treatment could be applied.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1198 Ministerio de Economía y Competitividad PSI2014-53524-P Ministerio de Economía y Competitividad PSI2017-83777
Note:	This work was partially supported by the Ministry of Economy and Competitiveness (Grant PSI2014-53524-P and PSI2017-83777) and the Agency of University and Research Funding Management of the Catalonia Government (Research Groups SGR2017-1198). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This work was partially supported by the Ministry of Economy and Competitiveness (Grant PSI2014-53524-P and PSI2017-83777) and the Agency of University and Research Funding Management of the Catalonia Government (Research Groups SGR2017-1198).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Aged ; Anxiety ; Case-control studies ; Central nervous system sensitization ; Depression ; Female ; Fibromyalgia ; Humans ; Male ; Middle aged ; Osteoarthritis ; Knee ; Psychometrics ; Sample size
Published in:	PloS one, Vol. 14, núm. 12 (2019) , p. e0225836, ISSN 1932-6203

DOI: 10.1371/journal.pone.0225836
PMID: 31805099

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