Temporal and geographical variability of prevalence and incidence of autism spectrum disorder diagnoses in children in Catalonia, Spain
Pérez-Crespo, Laura (Universitat Pompeu Fabra)
Prats-Uribe, Albert (Universitat Pompeu Fabra)
Tobias, Aurelio (Institut de Diagnosi Ambiental i Estudis de l'Aigua)
Duran-Tauleria, Enric (Institut Global d'Atenció Integral del Neurodesenvolupament (IGAIN))
Coronado Contreras, Ricard (Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva)
Hervás Zúñiga, Amaia (Institut Global d'Atenció Integral del Neurodesenvolupament (IGAIN))
Guxens, Mònica (Universitat Pompeu Fabra)

Fecha:	2019
Resumen:	This study aims to estimate the prevalence of autism spectrum disorders (ASD) in 2017 and the ASD diagnosis incidence between 2009 and 2017 in children living in Catalonia region in Spain, and their temporal and geographical variability. We used administrative data for all children aged 2-17 years who were insured in the public Catalan Health System between 2009 and 2017. We identified all ASD cases diagnosed between 2009 and 2017 (ICD-9 codes 299. 0, 299. 1, 299. 8, and 299. 9). We estimated the ASD prevalence in 2017 and the overall annual incidence between 2009 and 2017, then stratified by sex, age group, and healthcare area. We used Poisson regression models to assess temporal trends in the incidence and mixed-effects Poisson regression models to assess geographical variability. We observed an ASD prevalence of 1. 23% (95% confidence interval [CI] 1. 21-1. 25) in 2017, with 1. 95% (95% CI 1. 92-1. 99) for boys and 0. 46% (95% CI 0. 44-0. 48) for girls, the highest prevalence being in 11- to 17-year-olds (1. 80%, 95% CI 1. 76-1. 83). The ASD diagnosis incidence increased from 0. 07% (95% CI 0. 06-0. 09) in 2009 to 0. 23% (95% CI 0. 21-0. 24) in 2017, with a higher increase in girls, and in children aged 2-5 years at the time of diagnosis. We only observed geographical differences in prevalence in the 2017 data. We also detected a threefold increase in the diagnosis incidence overall, which was even more pronounced in girls and at early ages. In conclusion, the ASD prevalence observed in this study was 1. 23% in 2017, with a sex ratio of 4. 5 in favor of boys, which is consistent with previous studies.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Autistic disorder ; Child development disorder ; Neurodevelopmental disorders ; Epidemiology ; Europe
Publicado en:	Autism research, Vol. 12, núm. 11 (january 2019) , p. 1693-1705, ISSN 1939-3806

DOI: 10.1002/aur.2172
PMID: 31317678

13 p, 879.7 KB

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