Wobbly syndrome in an african pygmy hedgehog (Atelerix albiventris) : Neuropathological and immunohistochemical studies Síndrome de wobbly em um ouriço pigmeu africano (Atelerix albiventris): estudo neuropatológico e imuno-histoquímico
de Oliveira, L. B. (Universidade Federal de Minas Gerais (UFMG). Departamento de Clínica e Cirurgia)
Moreira, M. V. L. (Universidade Federal de Minas Gerais (UFMG). Departamento de Clínica e Cirurgia)
Santos, W. H. d. M. (Universidade Federal de Minas Gerais (UFMG). Departamento de Clínica e Cirurgia)
Stuart, L. C. O. (Universidade Federal de Minas Gerais (UFMG). Departamento de Clínica e Cirurgia)
Pi Castro, Dolors (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Ecco, R. (Universidade Federal de Minas Gerais (UFMG). Departamento de Clínica e Cirurgia)

Date:	2019
Abstract:	A three-year-old female African pygmy hedgehog (Atelerix albiventris), born and domiciled in Brazil, presented apathy, prostration, and difficulty to stay standing. Its parents were siblings but did not present clinical signs related to this condition. As its clinical condition worsened, the animal was euthanized and referred for necropsy. No gross lesions were found in the central nervous system (CNS). Histologically, there was vacuolation with axonal degeneration in the white matter of the CNS and in peripheral nervous tissue. The Kluver-Barrera (KB) stain confirmed demyelination in vacuolated areas. Immunohistochemistry using several neural markers confirmed astrocytosis and microgliosis associated with vacuolated areas. In addition, there was a mild decrease in the immuno intensity of myelin proteolipid protein (PLP) in these areas. These results suggest a genetic origin of the present demyelination, which resulted in the wobbly syndrome described in this report.
Note:	Scholarships were provided by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Finance Code 001. Additional support was provided by Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais (UFMG).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Portuguès
Document:	Article ; recerca ; Versió publicada
Subject:	Central nervous system ; Degenerative disease ; Myelopathy ; Histopathology ; Vacuolation
Published in:	Ciencia Rural, Vol. 49 Núm. 1 (2019) , p. e20180742, ISSN 1678-4596

DOI: 10.1590/0103-8478cr20180742

6 p, 3.1 MB

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