Clinical phenotypes of SARS-CoV-2 : implications for clinicians and researchers
Rello, Jordi (Hospital Universitari Vall d'Hebron)
Storti, Enrico (Hospitale de Lodi)
Belliato, Mirko (Fondazione IRCCS Policlinico San Matteo)
Serrano, R. (Complejo Hospitalario Universitario de Albacete)

Date:	2020
Abstract:	Patients with COVID-19 present a broad spectrum of clinical presentation. Whereas hypoxaemia is the marker of severity, different strategies of management should be customised to five specific individual phenotypes. Many intubated patients present with phenotype 4, characterised by pulmonary hypoxic vasoconstriction, being associated with severe hypoxaemia with "normal" (>40 mL·cmH2O-1) lung compliance and likely representing pulmonary microvascular thrombosis. Phenotype 5 is often associated with high plasma procalcitonin and has low pulmonary compliance, Which is a result of co-infection or acute lung injury after noninvasive ventilation. Identifying these clinical phenotypes and applying a personalised approach would benefit the optimisation of therapies and improve outcomes.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	ARDS ; SARS-CoV-2 ; COVID-19 ; Acute Lung Injury ; Betacoronavirus ; Biomarkers ; Biomedical Research ; Coronavirus Infections ; Disease Management ; Female ; Humans ; Hypoxia ; Lung Compliance ; Male ; Mechanical ventilation ; Pandemics ; Personalized medicine ; Phenotype ; Pneumonia, Viral ; Procalcitonin ; SARS Virus
Published in:	European respiratory journal, Vol. 55 Núm. 5 (january 2020) , ISSN 1399-3003

DOI: 10.1183/13993003.01028-2020
PMID: 32341111

14 p, 348.3 KB

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