Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA
Radua, Joaquim (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience)
Vieta, Eduard (Universitat de Barcelona)
Shinohara, Russell (Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA)
Kochunov, Peter (Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA)
Quidé, Yann (Neuroscience Research Australia, Sydney, NSW, Australia)
Green, Melissa J. (Neuroscience Research Australia, Sydney, NSW, Australia)
Weickert, Cynthia S. (Department of Neuroscience & Physiology, Upstate Medical University, Syracuse, Newyork, NY, USA)
Weickert, Thomas (Neuroscience Research Australia, Sydney, NSW, Australia)
Bruggemann, Jason (Neuroscience Research Australia, Sydney, NSW, Australia)
Kircher, Tilo (Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany)
Nenadić, Igor (Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany)
Cairns, Murray J. (Hunter Medical Research Institute, Newcastle, NSW, Australia)
Seal, Marc (The University of Melbourne, Australia)
Schall, Ulrich (Hunter Medical Research Institute, Newcastle, NSW, Australia)
Henskens, Frans (Health Behaviour Research Group, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia)
Fullerton, Janice M. (Neuroscience Research Australia, Sydney, NSW, Australia)
Mowry, Bryan (Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, QLD, Australia)
Pantelis, Christos (North Western Mental Health, Melbourne Health, Melbourne, VIC, Australia)
Lenroot, Rhoshel (University of New Mexico, Albuquerque, NM, USA)
Cropley, Vanessa (Melbourne Neuropsychiatry Centre, Dept. of Psychiatry, University of Melbourne, Melbourne, VIC, Australia)
Loughland, Carmel (University of Newcastle, Newcastle, NSW, Australia)
Scott, Rodney (University of Newcastle, Newcastle, NSW, Australia)
Wolf, Daniel H. (Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA)
Satterthwaite, Theodore D. (Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA)
Tan, Yunlong (Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China)
Sim, Kang (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore)
Piras, Fabrizio (Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy)
Spalletta, Gianfranco (Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA)
Banaj, Nerisa (Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy)
Pomarol-Clotet, Edith (FIDMAG Germanes Hospitalàries Research Foundation (Barcelona, Catalunya))
Solanes, Aleix (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Albajes-Eizagirre, Anton (FIDMAG Germanes Hospitalàries Research Foundation (Barcelona, Catalunya))
Canales-Rodriguez, Erick Jorge (Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland)
Sarro, Salvador (Universitat Internacional de Catalunya. Facultat de Medicina)
Giorgio, Annabella Di (Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari 'Aldo Moro', Bari, Italy)
Bertolino, Alessandro (Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari 'Aldo Moro', Bari, Italy)
Stäblein, Michael (Dept. of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany)
Oertel, Viola (Dept. of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany)
Knöchel, Christian (Dept. of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany)
Borgwardt, Stefan (Department of Psychiatry and Psychotherapy, University Lübeck, Germany)
du Plessis, Stefan (University of Stellenbosch, Cape Town, Western Province, South Africa)
Yun, Je-Yeon (Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea)
Kwon, Jun Soo (Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea)
Dannlowski, Udo (Department of Psychiatry, University of Münster, Münster, Germany)
Hahn, Tim (Department of Psychiatry, University of Münster, Münster, Germany)
Grotegerd, Dominik (Department of Psychiatry, University of Münster, Münster, Germany)
Alloz, Clara (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Arango, Celso (Universidad Complutense de Madrid. Facultad de Medicina)
Janssen, Joost (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Díaz-Caneja, Covadonga M (Universidad Complutense de Madrid. Facultad de Medicina)
Jiang, Wenhao (Georgia State University, Atlanta, GA, USA)
Calhoun, Vince (Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA)
Ehrlich, Stefan (Technische Universität Dresden, Faculty of Medicine, Division of Psychological and Social Medicine, Dresden, Germany)
Yang, Kun (Departments of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA)
Cascella, Nicola G. (Departments of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA)
Takayanagi, Yoichiro (Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA)
Sawa, Akira (Departments of Psychiatry, Neuroscience, and Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA)
Tomyshev, Alexander (Mental Health Research Center, Moscow, Russia)
Lebedeva, Irina (Mental Health Research Center, Moscow, Russia)
Kaleda, Vasily (Mental Health Research Center, Moscow, Russia)
Kirschner, Matthias (Montreal Neurological Institute, McGill University, Montreal, Canada)
Hoschl, Cyril (Department of Psychiatry and Clinical Psychology, Third Faculty of Medicine, Charles University, Prague, Czech Republic)
Tomecek, David (Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic)
Skoch, Antonin (MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic)
van Amelsvoort, Therese (Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands)
Bakker, Geor (Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands)
James, Anthony (Oxford University. Department of Psychiatry)
Preda, Adrian (Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA)
Weideman, Andrea (Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA)
Stein, Dan J. (SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, Western Province, South Africa)
Howells, Fleur (Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa)
Uhlmann, Anne (Department of Child and Adolescent Psychiatry, Technische Universität Dresden, Dresden, Germany)
Temmingh, Henk (Valkenburg Hospital, Observatory, Cape Town, Western Cape, South Africa)
López-Jaramillo, Carlos (Mood Disorders Program, Hospital Universitario San Vicente Fundación, Medellin, Colombia)
Díaz-Zuluaga, Ana M.. (Research Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellín, Antioquia, Colombia)
Fortea, Lydia (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Martinez-Heras, Eloy (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Solana, Elisabeth (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Llufriu, Sara (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Jahanshad, Neda (Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA)
Thompson, Paul (Imaging Genetics Center, Department of Neurology, University of Southern California, Los Angeles, CA, USA)
Turner, Jessica (Georgia State University, Atlanta, GA, USA)
van Erp, Theo (Center for the Neurobiology of Learning and Memory, University of California Irvine, 309 Qureshey Research Lab, Irvine, CA, 92697, USA)

Fecha:	2020
Resumen:	A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium combines neuroimaging data from many institutions worldwide. However, this introduces heterogeneity due to different scanning devices and sequences. ENIGMA projects commonly address this heterogeneity with random-effects meta-analysis or mixed-effects mega-analysis. Here we tested whether the batch adjustment method, ComBat, can further reduce site-related heterogeneity and thus increase statistical power. We conducted random-effects meta-analyses, mixed-effects mega-analyses and ComBat mega-analyses to compare cortical thickness, surface area and subcortical volumes between 2897 individuals with a diagnosis of schizophrenia and 3141 healthy controls from 33 sites. Specifically, we compared the imaging data between individuals with schizophrenia and healthy controls, covarying for age and sex. The use of ComBat substantially increased the statistical significance of the findings as compared to random-effects meta-analyses. The findings were more similar when comparing ComBat with mixed-effects mega-analysis, although ComBat still slightly increased the statistical significance. ComBat also showed increased statistical power when we repeated the analyses with fewer sites. Results were nearly identical when we applied the ComBat harmonization separately for cortical thickness, cortical surface area and subcortical volumes. Therefore, we recommend applying the ComBat function to attenuate potential effects of site in ENIGMA projects and other multi-site structural imaging work. We provide easy-to-use functions in R that work even if imaging data are partially missing in some brain regions, and they can be trained with one data set and then applied to another (a requirement for some analyses such as machine learning).
Ayudas:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1271 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1365 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT002-16-00331 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT006-17-00357 Instituto de Salud Carlos III CPII19-00009 Instituto de Salud Carlos III CPII13-00018 Instituto de Salud Carlos III CPII16-00018 Instituto de Salud Carlos III PI14-01151 Instituto de Salud Carlos III PI14-01148 Instituto de Salud Carlos III PI14-00292 Instituto de Salud Carlos III PI15-00277 Instituto de Salud Carlos III PI15-00283 Instituto de Salud Carlos III PI19-00394
Nota:	Altres ajuts: SRB: The Australian Schizophrenia Research Bank (ASRB) was supported by the National Health and Medical Research Council of Australia (NHMRC) (Enabling Grant, ID 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation and the Schizophrenia Research Institute. Chief Investigators for ASRB were Carr, V., Schall, U., Scott, R., Jablensky, A., Mowry, B., Michie, P., Catts, S., Henskens, F., Pantelis, C. We thank Loughland, C., the ASRB Manager, and acknowledge the help of Jason Bridge for ASRB database queries. CP was supported by NHMRC Senior Principal Research Fellowships (IDs: 628386 & 1105825); GC was supported by the Schizophrenia Research Institute utilizing infrastructure funding from the New South Wales Ministry of Health and New South Wales Ministry of Trade and Investment (Australia); JMF was supported by NHMRC project grant (1063960) and the Janette Mary O'Neil Research Fellowship; MJG was supported by NHMRC as an R.D. Wright Biomedical Career Development Fellow (1061875). MJC was supported by NHMRC Senior Research Fellowship (1121474). CASSI: CSW is funded by the NSW Ministry of Health, Office of Health and Medical Research. CSW is a recipient of a National Health and Medical Research Council (Australia) Principal Research Fellowship (PRF) (#1117079). CIAM: The CIAM study (FMH - PI) was supported by the University Research Committee, University of Cape Town and South African funding bodies National Research Foundation and Medical Research Council. COBRE: The COBRE dataset and investigators were supported by NIH grants R01EB006841 & P20GM103472, as well as NSF grant 1539067. JT (senior author) and VDC are supported by 5R01MH094524. JMS is supported by R01 AA021771 and P50 AA022534. EONCKS: This work was supported by a New Partnership for Africa's Development (NEPAD) grant through the Department of Science and Technology of South Africa, the Medical Research Council of South Africa (grant number 65174). ESO: The ESO study was funded by NPU I - LO1611 and Ministry of Health, Czech Republic - Conceptual Development of Research Organization 00023001 (IKEM). FIDMAG/Project: This work was supported by the Catalan Government and several grants from the Instituto de Salud Carlos III and co-funded by European Union (ERDF/ESF, 'Investing in your future'): Miguel Servet Research Contracts and Research Project Grants. FOR2107 Marburg: The FOR2107 Marburg study was funded by the German Research Foundation (DFG), Tilo Kircher (speaker FOR2107; DFG grant numbers KI588/14-1, KI588/14-2), Axel Krug (KR 3822/5-1, KR 3822/7-2), Igor Nenadic (NE 2254/1-2), Carsten Konrad (KO 4291/3-1). FOR2107 Muenster: The FOR2107 Muenster study was funded by the German Research Foundation (DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2 to UD) and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Münster (grant Dan3/012/17 to UD). TH was supported by grants from the German Research Foundation (DFG grants HA7070/2-2, HA7070/3, HA7070/4). Frankfurt: MRI was performed at the Frankfurt Brain Imaging Center, supported by the German Research Council (DFG) and the German Ministry for Education and Research (BMBF; Brain Imaging Center Frankfurt/Main, DLR 01GO0203). GIPSI: This study was supported by Colciencias PRISMA-U.T. Huilong1 & Huilong2: This study was funded by the National Natural Science Foundation of China (81761128021; 31671145; 81401115; 81401133), Beijing Municipal Science and Technology Commission grant (Z141107002514016) and Beijing Natural Science Foundation(7162087, Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding (XMLX201609; zylx201409). IGP: This study was funded by Project Grants from the Australian National Health and Medical Research Council of Australia (NHMRC; APP630471 and APP1081603), the Macquarie University's Australian Research Council Centre of Excellence in Cognition and its Disorders (CE110001021). Johns Hopkins: Supported by National Institutes of Health Grant Nos. MH-092443, MH-094268 (Silvio O. Conte Center), MH-105660, and MH-107730; foundation grants from Stanley, RUSK/S-R, and NARSAD/Brain and Behavior Research Foundation. Madrid: Supported by the Spanish Ministry of Science, Innovation and Universities, Instituto de Salud Carlos III, co-financed by ERDF Funds from the European Commission, "A way of making Europe", CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds and European Union Seventh Framework Program and H2020 Program; Fundación Familia Alonso, Fundación Alicia Koplowitz and Fundación Mutua Madrileña. MPRC1 & MPRC2: Support was received from NIH grants U01MH108148, 2R01EB015611, R01MH112180, R01DA027680, R01MH085646, P50MH103222 and T32MH067533, a State of Maryland contract (M00B6400091) and NSF grant (1620457). OLIN: The Olin study was supported by NIH grants R37MH43375 and R01MH074797. Oxford: The Oxford study MRC G0500092. SLF Rome: Support from the Italian Ministry of Health grants RC-12-13-14-15-16-17-18-19/A. RSCZ: RSCZ data collection was supported by RFBR 15-06-05758 grant. SCORE: This study was supported in part by grant 3232BO_119382 from the Swiss National Science Foundation. We thank the FePsy (Frueherkennung von Psychosen; early detection of psychosis) Study Group from the University of Basel, Department of Psychiatry, Switzerland, for the recruitment of the study participants. The FePsy Study was supported in part by grant No. SNF 3200-057216/1, ext./2, ext./3. Singapore: This study was supported by research grants from the National Healthcare Group, Singapore (SIG/05004; SIG/11003), and the Singapore Bioimaging Consortium (RP C-009/2006) research grants awarded to KS. SNUH: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (Grant no. 2013R1A2A1A03071089 and 2017M3C7A1029610). UCISZ: The UCISZ study was supported by the National Institutes of Mental Health grant number R21MH097196 to TGMvE. UCISZ data were processed by the UCI High Performance Computing cluster supported by Joseph Farran, Harry Mangalam, and Adam Brenner and the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1 TR000153. UNIBA: The UNIBA study was supported by grant funding from the Italian Ministry of Health (PE-2011-02347951). UNIMAAS: The study was supported by Dutch Organization for Health Research and Development (ZonMw 91112002) and a personal grant to Thérèse van Amelsvoort (ZonMw-VIDI: 91712394). The data was collected in a clinical trial registered in the Dutch clinical trial registry under ID: NTR5094 (http://www.trialregister.nl). UPenn: This study was supported by the National Institute of Mental Health grants MH064045, MH 60722, MH019112, MH085096 (DHW), and R01MH112847 (RTS and TDS). Zurich: This study was supported by the Swiss National Science Foundation (105314_140351 to S.K.). Matthias Kirschner acknowledges support from the National Bank Fellowship (McGill University) and the Swiss National Foundation (P2SKP3_178175). Research reported in this publication was also supported by the following National Institutes of Health grants: U54 EB020403 to PMT, R01 MH116147, U24 RR21992, R21MH097196, and TR000153 to TGMvE, S10 OD023696 and R01EB015611 to PK, T32 AG058507and 5T32 MH073526 to CRKC, R01 MH117601 to NJ, ENIGMA's NIH Big Data to Knowledge (BD2K) initiative U54 EB020403, ENIGMA Sex Differences R01MH116147, and ENIGMA-COINSTAC: Advanced World-wide Transdiagnostic Analysis of Valence System Brain Circuits R01MH121246.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Brain ; Cortical thickness ; Gray matter ; Mega-analysis ; Neuroimaging ; Schizophrenia ; Volume
Publicado en:	NeuroImage, Vol. 218 (may 2020) , p. 116956, ISSN 2213-1582

DOI: 10.1016/j.neuroimage.2020.116956
PMID: 32470572

39 p, 1.4 MB

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