Quantifying the under-reporting of uncorrelated longitudal data : the genital warts example
Moriña, David (Centre de Recerca Matemàtica)
Fernández-Fontelo, Amanda (Humboldt-Universität zu Berlin)
Cabaña Nigro, Alejandra (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
Puig, Pedro (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
Monfil, Laura (Institut Català d'Oncologia)
Brotons, Maria (Institut Català d'Oncologia)
Díaz Sanchís, Mireia (Institut Català d'Oncologia)

Fecha:	2021
Resumen:	Genital warts are a common and highly contagious sexually transmitted disease. They have a large economic burden and affect several aspects of quality of life. Incidence data underestimate the real occurrence of genital warts because this infection is often under-reported, mostly due to their specific characteristics such as the asymptomatic course. Genital warts cases for the analysis were obtained from the Catalan public health system database (SIDIAP) for the period 2009-2016. People under 15 and over 94 years old were excluded from the analysis as the incidence of genital warts in this population is negligible. This work introduces a time series model based on a mixture of two distributions, capable of detecting the presence of under-reporting in the data. In order to identify potential differences in the magnitude of the under-reporting issue depending on sex and age, these covariates were included in the model. This work shows that only about 80% in average of genital warts incidence in Catalunya in the period 2009-2016 was registered, although the frequency of under-reporting has been decreasing over the study period. It can also be seen that this issue has a deeper impact on women over 30 years old. Although this study shows that the quality of the registered data has improved over the considered period of time, the Catalan public health system is underestimating genital warts real burden in almost 10,000 cases, around 23% of the registered cases. The total annual cost is underestimated in about 10 million Euros respect the 54 million Euros annually devoted to genital warts in Catalunya, representing 0. 4% of the total budget.
Ayudas:	Ministerio de Economía y Competitividad MDM-2014-0445 Ministerio de Economía y Competitividad PIE16/00049 Ministerio de Economía y Competitividad PI16/01254 Ministerio de Economía y Competitividad PI16/01056 Ministerio de Economía y Competitividad PI19/01118 Ministerio de Economía y Competitividad CM15/00061 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1718 Agència de Gestió d'Ajuts Universitaris i de Recerca 0599S/7613/2010 Agencia Estatal de Investigación RTI2018-096072-B-I00
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan aquestes es distribueixin sota la mateixa llicència que regula l'obra original i es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Genital warts ; Estimation ; HPV ; Under-reporting ; Time series
Publicado en:	BMC Medical Research Methodology, Vol. 21 (January 2021) , art. 6, ISSN 1471-2288

DOI: 10.1186/s12874-020-01188-4
PMID: 33407173

7 p, 483.1 KB

El registro aparece en las colecciones:
Artículos > Artículos de investigación
Artículos > Artículos publicados