Efficacy of medium chain triglyceride oil dietary supplementation in reducing seizure frequency in dogs with idiopathic epilepsy without cluster seizures : a non-blinded, prospective clinical trial
Molina, Jenifer (Nestlé Purina PetCare EMENA)
Jean-Philippe, Clementine (Nestlé Purina)
Conboy, Lisa (Nestlé Purina)
Añor Torres, Sònia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
de la Fuente, Cristian (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Wrzosek, Marcin Adam (Uniwersytet Przyrodniczy we Wroclawiu)
Spycher, Andrea (Tierarztpraxis Bärn West GmbH)
Luchsinger, Eva (Tierarztpraxis DUOVet AG)
Wenger-Riggenbach, Bettina (Bessy's Kleintierklinik AG)
Montoliu Stevers, Patricia (Ars Veterinaria)
Gandini, Gualtiero (University of Bologna)
Menchetti, Marika (University of Bologna)
Ribeiro, João Carlos (University of Lisbon. Faculty of Veterinary Medicine)
Varejão, Artur (University of Trás-os-Montes e Alto Douro)
Ferreira, Antonio (University of Lisbon. Faculty of Veterinary Medicine)
Zanghi, Brian (Nestle Purina PetCare)
Volk, Holger Andreas (University of Veterinary Medicine)

Date:	2020
Abstract:	Despite appropriate antiseizure drug (ASD) treatment, around two-thirds of dogs with idiopathic epilepsy (IE) have seizures long-term and 20-30per cent of affected dogs remain poorly controlled. The current study aim is to test in a field trial the efficacy and tolerability of a commercially available diet enriched with 6. 5per cent medium chain triglyceride (MCT) oil in dogs (n=21) with at least a tier 1 idiopathic epilepsy diagnosis, without cluster seizures, in 10 veterinary practices across Europe. Each dog's quality of life (QoL), ataxia, sedation and frequency and severity of seizures were recorded by owners throughout the study. The mean seizure frequency per month, averaged over the entire 84-day study, significantly (P=0. 04) decreased 32per cent compared with the baseline monthly seizure frequency recorded during the month immediately before feeding the diet. Similarly, the seizure days rate (days/month) also declined (P<0. 001) by 42per cent. QoL was reported as very good to excellent (>8. 5/10) in 20 of the 21 dogs before starting the diet and this remained unchanged during the trial. This study demonstrates the use of a diet enriched with MCTs as an adjunct to ASD treatment may have some antiseizure properties for dogs diagnosed with IE, as demonstrated in previous studies.
Note:	This study was fully funded by Nestlé Purina Research
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Canine ; Diet ; Epilepsy ; Medium chain triglycerides ; Seizures
Published in:	The veterinary record, Vol. 187 (october 2020) , p. 356, ISSN 2042-7670

DOI: 10.1136/vr.105410
PMID: 32532842

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