Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus
Gazeta, Rosa Estela (Pediatrics Department, Jundiaí Medical School)
Bertozzi, Ana Paula Antunes Pascalicchio (Pediatrics Department, Jundiaí Medical School)
Dezena, Rita de Cássia de Aguirre Bernardes (University Center Campo Limpo Paulista-UNIFACCAMP)
Silva, Andrea Cristina Botelho (Pediatric Infectology Laboratory, Jundiaí Medical School)
Fajardo, Thamirys Cosmo Gillo (Pediatric Infectology Laboratory, Jundiaí Medical School)
Catalan, Daniel T. (Pediatric Infectology Laboratory, Jundiaí Medical School, Jundiaí 13202-550)
Rizzo, Maria de Fátima Valente (Pediatrics Department, Jundiaí Medical School, Jundiaí 13202-550)
Moron, Antonio Fernandes (Tropical Medicine Institute, Campus São Paulo, University of São Paulo (USP))
Soriano-Arandes, Antoni (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Clemente, Nuria Sanchez (Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine)
Quintella, Tania (Pontifícia Universidade Católica de Campinas. Departamento de Pediatría)
Ventura, Dora Fix (Department of Experimental Psychology, Institute of Psychology, Campus São Paulo, University of São Paulo)
Damico, Francisco Max (Department of Experimental Psychology, Institute of Psychology, Campus São Paulo, University of São Paulo)
França, Valtenice de Cassia Rodrigues de Matos (Department of Experimental Psychology, Institute of Psychology, Campus São Paulo, University of São Paulo)
de Almeida, Juliana Paula Gomes (Pediatric Neurology Department, School of Medical Sciences of Santa Casa de São Paulo)
Zara, Ana Laura de Sene Amâncio (Department of Collective Health, Tropical InstitutePathology and Public Health, Federal University of Goiás)
Pires, Lucas Castro (Faculty of Medicine, Jundiaí Medical School)
Jundiaí, Cohort Zika vírus (Cohort Zika vírus Jundiaí)
Passos, Saulo Duarte (Pediatrics Department, Jundiaí Medical School)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	Congenital Zika virus (ZIKV) infection may present with a broad spectrum of clinical manifestations. Some sequelae, particularly neurodevelopmental problems, may have a later onset. We conducted a prospective cohort study of 799 high-risk pregnant women who were followed up until delivery. Eighty-three women and/or newborns were considered ZIKV exposed and/or infected. Laboratory diagnosis was made by polymerase chain reaction in the pregnant mothers and their respective newborns, as well as Dengue virus, Chikungunya virus, and ZIKV serology. Serology for toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, and syphilis infections were also performed in microcephalic newborns. The newborns included in the study were followed up until their third birthday. Developmental delay was observed in nine patients (13. 2%): mild cognitive delay in three patients, speech delay in three patients, autism spectrum disorder in two patients, and severe neurological abnormalities in one microcephalic patient; sensorineural hearing loss, three patients and dysphagia, six patients. Microcephaly due to ZIKV occurred in three patients (3. 6%). Clinical manifestations can appear after the first year of life in children infected/exposed to ZIKV, emphasizing the need for long-term follow-up.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Zika virus ; Congenital infection ; Microcephaly ; Cohort studies
Publicado en:	Viruses, Vol. 13 (march 2021) , ISSN 1999-4915

DOI: 10.3390/v13030523
PMID: 33810110

15 p, 839.6 KB

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