Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria
Kolkhir, Pavel (Charité - Universitätsmedizin Berlin)
Altrichter, Sabine (Charité - Universitätsmedizin Berlin)
Asero, Riccardo (Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano)
Daschner, Alvaro (Instituto de Investigación Hospital Universitario de la Princesa)
Ferrer, Marta (Instituto de Investigación Sanitaria de Navarra)
Giménez-Arnau, Ana M 1961- (Universitat Autònoma de Barcelona. Departament de Medicina)
Hawro, Tomasz (Charité - Universitätsmedizin Berlin)
Jakob, Thilo (Justus Liebig Universität Giessen)
Kinaciyan, Tamar (Medical University of Vienna)
Kromminga, Arno (Bioagilytix Europe GmbH, Hamburg)
Konstantinou, George (General Military Training Hospital (Tessalònica, Grècia))
Makris, Michael (University General Hospital Attikon (Haidari, Grècia))
Metz, Martin (Charité - Universitätsmedizin Berlin)
Skov, Per Stahl (RefLab ApS, Copenhagen)
Staubach, Petra (University Medical Center Mainz)
Sussman, Gordon (University of Toronto)
Zhang, Ke (David Geffen School of Medicine at UCLA)
Maurer, Marcus (Charité - Universitätsmedizin Berlin)

Fecha:	2021
Resumen:	Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases. We analyzed records of CSU patients (n = 1,199) for a history or presence of autoimmune diseases. Patients were diagnosed with type IIb autoimmune CSU (aiCSU) if all 3 tests were positive: autologous serum skin test (ASST), basophil histamine release assay (BHRA) and/or basophil activation test (BAT), and IgG autoantibodies against FcεRIα/IgE detected by immunoassay. Twenty-eight percent of CSU patients had at least 1 autoimmune disease. The most prevalent autoimmune diseases were Hashimoto's thyroiditis (HT) (≥ 21%) and vitiligo (2%). Two percent of CSU patients had ≥ 2 autoimmune diseases, most frequently HT plus vitiligo. Comorbid autoimmune diseases, in patients with CSU, were associated with female sex, a family history of autoimmune diseases, and higher rates of hypothyroidism and hyperthyroidism (P < 0. 001). Presence of autoimmune diseases was linked to aiCSU (P = 0. 02). The risks of having autoimmune diseases were 1. 7, 2. 9 and 3. 3 times higher for CSU patients with a positive ASST, BHRA and BAT, respectively. In CSU patients, markers for autoimmune diseases, antinuclear antibodies and/or IgG anti-thyroid antibodies were associated with non-response to omalizumab treatment (P = 0. 013). In CSU, autoimmune diseases are common and linked to type IIb autoimmune CSU. Our results suggest that physicians assess and monitor all adult patients with CSU for signs and symptoms of common autoimmune diseases, especially HT and vitiligo.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Chronic urticaria ; Autoimmune diseases ; Autoimmune thyroiditis ; Autoantibodies ; Autoimmunity ; Omalizumab ; Vitiligo ; Immunoassay
Publicado en:	Allergy, Asthma & Immunology Research, Vol. 13 (february 2021) , p. 545-559, ISSN 2092-7363

DOI: 10.4168/aair.2021.13.4.545
PMID: 34212543

15 p, 1.9 MB

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