Propagation patterns of jejunal motor activity measured by high-resolution water-perfused manometry
Alcalá-González, Luis Gerardo (Universitat Autònoma de Barcelona. Departament de Medicina)
Malagelada Prats, Carolina (Hospital Universitari Vall d'Hebron)
Galán Hidalgo, Carmen (Universitat Autònoma de Barcelona. Departament de Medicina)
Nieto Ruiz, Adoración (Universitat Autònoma de Barcelona. Departament de Medicina)
Accarino, Ana María (Universitat Autònoma de Barcelona. Departament de Medicina)
Azpiroz Vidaur, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2021
Abstract:	Background: The manometric diagnosis of severe intestinal dysmotility is performed at most institutions using catheters with 2-8 sensors 5-10 cm apart. The recent application of high-resolution manometry catheters with closely spaced sensors to other gut segments has been highly successful. The objective of the present study was to determine the feasibility of a jejunal high-resolution manometry method and to carry out a descriptive analysis of normal jejunal motor function. Methods: A 36-channel high-resolution water-perfused manometry catheter (MMS-Laborie, Enschede, The Netherlands) was orally placed in the jejunum of 18 healthy subjects (10 men, eight women; 21-38 age range). Intestinal motility was recorded during 5 h, 3 during fasting, and 2 after a 450 kcal solid-liquid meal. Analysis of motility patterns was supported by computerized tools. Key Results: All healthy subjects except one showed at least one complete migrating motor complex during the 3 h fasting period. Phase III activity lasted 5 ± 1 min and migrated aborally at a velocity of 7 ± 3 cm/min. High-resolution spatial analysis showed that during phase III each individual contraction propagated rapidly (75 ± 37 cm/min) over a 32 ± 10 cm segment of the jejunum. During phase II, most contractile activity corresponded to propagated contractile events which increased in frequency from early to late phase II (0. 5 ± 0. 9 vs 2. 5 ± 1. 3 events/10 min, respectively; p < 0. 001). After meal ingestion, non-propagated activity increased, whereas propagated events were less frequent than during late phase II. Conclusions & Inferences: Jejunal motility analysis with high-resolution manometry identifies propagated contractile patterns which are not apparent with conventional manometric catheters.
Grants:	Instituto de Salud Carlos III PI17/01794 Ministerio de Economía y Competitividad SAF 2016-76648-R Instituto de Salud Carlos III CM20/00182
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	High-resolution intestinal manometry ; Intestinal motility ; Postprandial motility ; Propagated contractions
Published in:	Neurogastroenterology and Motility, 33 (2021) , ISSN 1365-2982

DOI: 10.1111/nmo.14240
PMID: 34378830

8 p, 1.5 MB

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