The Impact of Bariatric Surgery on the Muscle Mass in Patients with Obesity : 2-Year Follow-up
Comas Martínez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Fidilio, Enzamaria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Palmas Candia, Fiorella (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Filippi-Arriaga, Francesca (Hospital Universitari Vall d'Hebron)
Vilallonga, Ramon (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Cordero-Vazquez, Efrain (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hernández, Irene (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Zabalegui Eguinoa, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Burgos Peláez, Rosa (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vila-Martí, Anna (Universitat de Vic - Universitat Central de Catalunya)
Simó Canonge, Rafael (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Ciudin, Andreea (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)

Date:	2021
Abstract:	Purpose: Bariatric surgery (BS) induces a significant and sustained weight loss in patients with severe obesity (SO). Nevertheless, apart from significantly reducing body fat, fat-free mass (FFM) might also be lost. At present, there is little and controversial data in the literature regarding the impact of BS on FFM. In recent years, bioimpedance (BIA) has emerged as a reliable test to assess body composition easily to use in the daily clinical practice. On the bases, the aim of the present study is to evaluate the impact of BS on the FFM, evaluated by means of BIA. Material and Methods: This is a prospective, observational study, including consecutive patients with SO that underwent BS between February 2018 and February 2019 at our center. At baseline, 1, 6, 12, and 24 months after the BS, all the patients underwent complete medical history, physical and anthropometric evaluation, and body composition assessment by means of BIA (using Bodystat QuadScan4000®). Results: Eighty-five patients with SO were recruited, 72. 9% females, aged 45. 54 ± 9. 98 years, pre-BS BMI 43. 87 ± 6. 52 kg/m. FFM significantly decreased continuously after BS at all timepoints. The loss of FFM 24 months post-BS accounted for approximately 21. 71 ± 13. 9% of the total weight loss, and was independent of BS technique or protein metabolism. Pre-BS HOMA-IR and FFM were independent predictors of FFM at 24 months. Conclusions: Significant and early loss of FFM in patients with SO that undergo BS was seen, not related to protein metabolism parameters or the BS technique used, suggesting an independent mechanism. Graphical abstract: [Figure not available: see fulltext. ].
Grants:	Instituto de Salud Carlos III PI20/01806
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Morbid obesity ; Fat-free mass ; Bariatric surgery ; Sarcopenic obesity
Published in:	Obesity Surgery, Vol. 32 (2021) p. 625-633, ISSN 1708-0428

DOI: 10.1007/s11695-021-05815-x
PMID: 34846686

9 p, 776.6 KB

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