The Association Between Diabetes Mellitus and Risk of Sarcopenia : Accumulated Evidences From Observational Studies
Qiao, Yu-Shun (Beijing Tongren Hospital, Capital Medical University)
Chai, Yin-He (Beijing Tongren Hospital)
Gong, Hong-Jian (Beijing Tongren Hospital)
Zhuldyz, Zhiyessova (Beijing Tongren Hospital)
Stehouwer, Coen D. A. (Maastricht University Medical Center)
Zhou, Jian-Bo (Beijing Tongren Hospital)
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	We performed a meta-analysis of observational studies to evaluate the association between the presence of sarcopenia and HbA1c, prediabetes, diabetes and diabetic complications. The PubMed, Embase, Cochrane and Web of Science databases were searched from inception to May 2021. We included full-text English language articles that reported the prevalence of sarcopenia in patients with and without diabetes. Quality assessment was performed according to the Newcastle- Ottawa scale for observational studies. Sixteen studies were included in the meta-analysis. Three studies showed that high HbA1c levels lead to loss of muscle mass, and one study involving prediabetes showed that people with prediabetes had lower muscle mass, strength, and performance than non-diabetic population. Seven studies showed that people with diabetes had a higher risk of sarcopenia than those without diabetes (combined OR: 2. 09, 95% CI:1. 62-2. 70). The remaining five studies suggested that diabetic complications increased the risk of sarcopenia (combined OR: 2. 09,95% CI:1. 62-2. 70). High HbA1c levels, prediabetes, diabetes and diabetes complications were associated with an increased risk of sarcopenia. Therapeutic strategies addressed to avoid the conversion of IGT to diabetes and to optimize glycemic control are warranted to prevent or arrest sarcopenia in the diabetic population.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Sarcopenia ; HbA1c ; Prediabetes ; Diabetic complications ; Diabetes mellitus ; Observational study
Published in:	Frontiers in endocrinology, Vol. 12 (december 2021) , ISSN 1664-2392

DOI: 10.3389/fendo.2021.782391
PMID: 35002965

10 p, 2.0 MB

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