Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
Fernández de Gamarra-Oca, Lexuri (Universidad de Deusto)
Zubiaurre-Elorza, Leire (Universidad de Deusto)
Junqué, Carme (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Solana, Elisabeth (Hospital Clínic i Provincial de Barcelona)
Soria-Pastor, Sara (Hospital de Mataró. Consorci Sanitari del Maresme)
Vázquez, Élida (Hospital Universitari Vall d'Hebron)
Delgado Martínez, Ignacio (Hospital Universitari Vall d'Hebron)
Macaya Ruiz, Alfons (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Ojeda, Natalia (Universidad de Deusto)
Poca Pastor, María Antonia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	Preterm newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) are at a higher risk of evidencing neurodevelopmental alterations. Present study aimed to explore the long-term effects that GM-IVH have on hippocampal subfields, and their correlates with memory. The sample consisted of 58 participants, including 36 preterm-born (16 with GM-IVH and 20 without neonatal brain injury), and 22 full-term children aged between 6 and 15 years old. All participants underwent a cognitive assessment and magnetic resonance imaging study. GM-IVH children evidenced lower scores in Full Intelligence Quotient and memory measures compared to their low-risk preterm and full-term peers. High-risk preterm children with GM-IVH evidenced significantly lower total hippocampal volumes bilaterally and hippocampal subfield volumes compared to both low-risk preterm and full-term groups. Finally, significant positive correlations between memory and hippocampal subfield volumes were only found in preterm participants together; memory and the right CA-field correlation remained significant after Bonferroni correction was applied (p = . 002). In conclusion, memory alterations and both global and regional volumetric reductions in the hippocampus were found to be specifically related to a preterm sample with GM-IVH. Nevertheless, results also suggest that prematurity per se has a long-lasting impact on the association between the right CA-field volume and memory during childhood.
Ayudas:	Agencia Estatal de Investigación PSI2017-83657-P Ministerio de Educación y Ciencia AP2008-0935 Ministerio de Educación y Ciencia AP2005-0047
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Brain ; Paediatric research
Publicado en:	Scientific reports, Vol. 11 (january 2021) , ISSN 2045-2322

DOI: 10.1038/s41598-021-81802-7
PMID: 33510243

11 p, 1.2 MB

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