Association of myostatin, a cytokine released by muscle, with inflammation in rheumatoid arthritis
Murillo-Saich, Jessica D. (UC San Diego School of Medicine)
Vazquez-Villegas, Maria Luisa (Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara)
Ramirez-Villafaña, Melissa (Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara)
Saldaña-Cruz, Ana Miriam (Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara)
Aceves-Aceves, Javier A. (Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara)
Gonzalez-Lopez, Laura (Hospital General Regional 110 (Mèxic))
Guma, Monica 1971- (Universitat Autònoma de Barcelona. Departament de Medicina)
Gamez-Nava, Jorge I. (Unidad de Investigacion Biomedica 02 IMSS (Mèxic))

Fecha:	2021
Resumen:	Supplemental Digital Content is available in the text Myostatin is a cytokine produced and released by myocytes that might have an outstanding role not only in muscle wasting during cachexia but also in inflammation. Herein we explore the association between myostatin levels and inflammatory parameters in rheumatoid arthritis (RA). One hundred twenty-seven women without rheumatic diseases and 84 women with a diagnosis of RA were assessed in a cross-sectional study. Outcomes reflecting the activity of the arthritis including Disease Activity Score (DAS28-ESR) and impairment in functioning by the Health Assessment Questionnaire-Disability Index were assessed in RA. We obtained Skeletal muscle mass index (SMI), fat-free mass index (FFMI), and fat mass index using dual-energy x-ray absorptiometry. Serum myostatin was determined by enzyme-linked immunosorbent assay. Myostatin levels were correlated with disease activity and parameters of muscle mass. The SMI was lower and concentration of myostatin was higher in RA patients than in controls (P = . 008 and P < . 001, respectively). Myostatin significantly positively correlated with C-reactive protein (rho = 0. 48, P < . 001), erythrocyte sedimentation rate (rho = 0. 28, P = . 009), and DAS28-ESR (rho = 0. 22, P = . 04), and negatively correlated with SMI (rho = −0. 29, P = . 008), (FFMI) (rho = −0. 24, P = . 027). In the multivariate logistic regression analysis, levels of myostatin remained associated with disease activity in RA (P = . 027). In our study, myostatin was associated with disease activity in RA patients, suggesting a mechanistic link between myostatin, muscle wasting and inflammation in RA.
Nota:	Instituto Mexicano del Seguro Social, Fondo de Investigacion en Salud, FIS/IMSS/PROT/MD16/1565
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Diseases activity ; Inflammation ; Muscle ; Myopenia ; Myostatin ; Rheumatoid arthritis ; Rheumatoid cachexia
Publicado en:	Medicine, Vol. 100 (january 2021) , ISSN 1536-5964

DOI: 10.1097/MD.0000000000024186
PMID: 33546034

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