Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models : protocol for a systematic review and meta-analysis
Carla, Adrien (CHU Clermont-Ferrand)
Pereira, Bruno (CHU Clermont-Ferrand)
Boukail, Hanifa (CHU Clermont-Ferrand)
Audard, Jules (Université Clermont Auvergne)
Pinol-Domenech, Nathalie (Université Clermont Auvergne)
De Carvalho, Manuela (Université Clermont Auvergne)
Blondonnet, Raiko (Université Clermont Auvergne)
Zhai, Ruoyang (Université Clermont Auvergne. GReD)
Morand, Dominique (CHU Clermont-Ferrand)
Lambert, Céline (CHU Clermont-Ferrand)
Sapin, Vincent (CHU Clermont-Ferrand)
Ware, Lorraine B. (Vanderbilt University Medical Center)
Calfee, Carolyn S. (University of California San Francisco)
Bastarache, Julie A. (Vanderbilt University)
Laffey, John (National University of Ireland Galway)
Juffermans, Nicole P. (Amsterdam UMC. University Medical Center)
Bos, Lieuwe D.. (University Medical Center)
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Rocco, Patricia R. M. (Federal University of Rio de Janeiro)
Matthay, Michael A. (University of California San Francisco)
McAuley, Daniel F. (Queens University Belfast)
Constantin, Jean-Michel (Sorbonne University)
Jabaudon, Matthieu (Vanderbilt University Medical Center)
Universitat Autònoma de Barcelona

Fecha:	2020
Resumen:	Subphenotypes were recently reported within clinical acute respiratory distress syndrome (ARDS), with distinct outcomes and therapeutic responses. Experimental models have long been used to mimic features of ARDS pathophysiology, but the presence of distinct subphenotypes among preclinical ARDS remains unknown. This review will investigate whether: 1) subphenotypes can be identified among preclinical ARDS models; 2) such subphenotypes can identify some responsive traits. We will include comparative preclinical (in vivo and ex vivo) ARDS studies published between 2009 and 2019 in which pre-specified therapies were assessed (interleukin (IL)-10, IL-2, stem cells, beta-agonists, corticosteroids, fibroblast growth factors, modulators of the receptor for advanced glycation end-products pathway, anticoagulants, and halogenated agents) and outcomes compared to a control condition. The primary outcome will be a composite of the four key features of preclinical ARDS as per the American Thoracic Society consensus conference (histologic evidence of lung injury, altered alveolar-capillary barrier, lung inflammatory response, and physiological dysfunction). Secondary outcomes will include the single components of the primary composite outcome, net alveolar fluid clearance, and death. MEDLINE, Embase, and Cochrane databases will be searched electronically and data from eligible studies will be extracted, pooled, and analyzed using random-effects models. Individual study reporting will be assessed according to the Animal Research: Reporting of In Vivo Experiments guidelines. Meta-regressions will be performed to identify subphenotypes prior to comparing outcomes across subphenotypes and treatment effects. This study will inform on the presence and underlying pathophysiological features of subphenotypes among preclinical models of ARDS and should help to determine whether sufficient evidence exists to perform preclinical trials of subphenotype-targeted therapies, prior to potential clinical translation. PROSPERO (ID: ).
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article de revisió ; recerca ; Versió publicada
Materia:	Systematic review protocol ; Acute respiratory distress syndrome ; Preclinical ; Subphenotypes
Publicado en:	Respiratory Research, Vol. 21 (april 2020) , ISSN 1465-993X

DOI: 10.1186/s12931-020-01337-9
PMID: 32264897

10 p, 538.1 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Instituto de Investigación e Innovación Parc Taulí (I3PT)
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