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Página principal > Artículos > Artículos publicados > Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer |
Fecha: | 2020 |
Resumen: | Identifying novel actionable factors that critically contribute to tumorigenesis is essential in ovarian cancer, an aggressive and disseminative tumor, with limited therapeutic options available. Here we show that Aurora Borealis (BORA), a mitotic protein that plays a key role in activating the master mitotic kinase polo-like kinase 1 (PLK1), has an oncogenic role in ovarian cancer. Gain and loss of function assays on mouse models and ex vivo patient-derived ascites cultures revealed an oncogenic role of BORA in tumor development and a transcriptome-analysis in clinically representative models depicted BORA's role in survival, dissemination and inflammatory cancer related-pathways. Importantly, combinatory treatments of FDA-approved inhibitors against oncogenic downstream effectors of BORA displayed synergistic effect in ovarian cancer models, offering promising therapeutic value. Altogether, our findings uncovered for the first time a critical role of BORA in the viability of human cancer cells providing potential novel therapeutic opportunities for ovarian cancer management. |
Ayudas: | Ministerio de Economía y Competitividad CB16/12/00328 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017 SGR 1661 Ministerio de Economía y Competitividad RTC-2015-3821 Ministerio de Economía y Competitividad PI15/00238 Ministerio de Economía y Competitividad CP13/00158 Ministerio de Economía y Competitividad CPII18/00027 Ministerio de Economía y Competitividad CPII16/00006 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | PLK1 ; BORA ; Ovarian cancer ; Mitosis ; Oncogene ; Targeted therapy |
Publicado en: | Cancers, Vol. 12 (april 2020) , ISSN 2072-6694 |
25 p, 12.2 MB |