Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders : Useful Nutraceuticals?
Martínez Perea, Vicente (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Iriondo De-Hond, Amaia (Instituto de Investigación en Ciencias de la Alimentación)
Borrelli, Francesca (University of Naples Federico II)
Capasso, Raffaele (University of Naples Federico II)
del Castillo, María Dolores (Instituto de Investigación en Ciencias de la Alimentación)
Abalo, Raquel (Universidad Rey Juan Carlos)

Fecha:	2020
Resumen:	Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used for different purposes, like the production of fibers, the production of oil from the seeds, and especially for recreational or medical purposes. Phytocannabinoids (terpenophenolic compounds derived from the plant), include the well-known psychoactive cannabinoid Δ 9 -tetrahydrocannabinol, and many non-psychoactive cannabinoids, like cannabidiol. The endocannabinoid system (ECS) comprises of endocannabinoid ligands, enzymes for synthesis and degradation of such ligands, and receptors. This system is widely distributed in the gastrointestinal tract, where phytocannabinoids exert potent effects, particularly under pathological (i. e. , inflammatory) conditions. Herein, we will first look at the hemp plant as a possible source of new functional food ingredients and nutraceuticals that might be eventually useful to treat or even prevent gastrointestinal conditions. Subsequently, we will briefly describe the ECS and the general pharmacology of phytocannabinoids. Finally, we will revise the available data showing that non-psychoactive phytocannabinoids, particularly cannabidiol, may be useful to treat different disorders and diseases of the gastrointestinal tract. With the increasing interest in the development of functional foods for a healthy life, the non-psychoactive phytocannabinoids are hoped to find a place as nutraceuticals and food ingredients also for a healthy gastrointestinal tract function.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cannabidiol ; Cannabinoids ; Inflammatory bowel disease ; Irritable bowel syndrome ; Gastrointestinal ; Non-psychoactive cannabinoids ; Nutraceutical ; Psychoactive cannabinoids ; Visceral pain
Publicado en:	International journal of molecular sciences, Vol. 21 (april 2020) , ISSN 1422-0067

DOI: 10.3390/ijms21093067
PMID: 32357565

35 p, 2.8 MB

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