European headache federation consensus on the definition of resistant and refractory migraine
Sacco, Simona (Regional Referral Headache Center of the Abruzzo region)
Braschinsky, Mark (Tartu University Clinics)
Ducros, Anne (University Hospital of Montpellier (França))
Lampl, Christian (Hospital Barmherzige Brüder)
Little, Patrick (European Migraine & Hendrik Ido Ambacht)
van den Brink, Antoinette Maassen (Erasmus MC University Medical Center Rotterdam)
Pozo-Rosich, Patricia (Hospital Universitari Vall d'Hebron)
Reuter, Uwe (Charité - Universitätsmedizin Berlin)
de la Torre, Elena Ruiz (Hendrik Ido Ambacht)
Del Rio, Margarita Sanchez (Clínica Universidad de Navarra)
Sinclair, Alexandra J. (Birmingham Health Partners)
Katsarava, Zaza (IM Sechenov First Moscow State Medical University)
Martelletti, Paolo (Sant'Andrea Hospital)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Despite advances in the management of headache disorders, some patients with migraine do not experience adequate pain relief with acute and preventive treatments. It is the aim of the present document to provide a definition of those migraines which are difficult-to-treat, to create awareness of existence of this group of patients, to help Healthcare Authorities in understanding the implications, and to create a basis to develop a better pathophysiological understanding and to support further therapeutic advances. Definitions were established with a consensus process using the Delphi method. Patients with migraine with or without aura or with chronic migraine can be defined as having resistant migraine and refractory migraine according to previous preventative failures. Resistant migraine is defined by having failed at least 3 classes of migraine preventatives and suffer from at least 8 debilitating headache days per month for at least 3 consecutive months without improvement; definition can be based on review of medical charts. Refractory migraine is defined by having failed all of the available preventatives and suffer from at least 8 debilitating headache days per month for at least 6 consecutive months. Drug failure may include lack of efficacy or lack of tolerability. Debilitating headache is defined as headache causing serious impairment to conduct activities of daily living despite the use of pain-relief drugs with established efficacy at the recommended dose and taken early during the attack; failure of at least two different triptans is required. We hope, that the updated EHF definition will be able to solve the conflicts that have limited the use of definitions which have been put forward in the past. Only with a widely accepted definition, progresses in difficult-to-treat migraine can be achieved. This new definition has also the aim to increase the understanding of the impact of the migraine as a disease with all of its social, legal and healthcare implications. It is the hope of the EHF Expert Consensus Group that the proposed criteria will stimulate further clinical, scientific and social attention to patients who suffer from migraine which is difficult-to-treat.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Migraine ; Chronic migraine ; Resistant migraine ; Refractory migraine ; Intractable migraine
Published in:	Journal of headache and pain, Vol. 21 (june 2020) , ISSN 1129-2377

DOI: 10.1186/s10194-020-01130-5
PMID: 32546227

12 p, 2.1 MB

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