Systemic Regulatory T Cells and IL-6 as Prognostic Factors for Anatomical Improvement of Uveitic Macular Edema
Matas, Jessica (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Llorenç, Victor (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Fonollosa, Alex (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Diaz Valle, David (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Esquinas, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
de la Maza, Maria Teresa Sainz (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Figueras-Roca, Marc (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Artaraz, Joseba (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Berasategui, Barbara (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Mesquida, Marina (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Adan Civera, Alfredo (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Molins, Blanca (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Universitat Autònoma de Barcelona

Fecha:	2020
Resumen:	To investigate whether systemic immune mediators and circulating regulatory T cells (Tregs) could be prognostic factors for anatomic outcomes in macular edema secondary to non-infectious uveitis (UME). Multicenter, prospective, observational, 12-month follow-up study of 60 patients with UME. Macular edema was defined as central subfield thickness (CST) > 300 μm measured with spectral domain optical coherence tomography (SD-OCT). Serum samples and peripheral blood mononuclear cells (PBMC) were obtained from venous blood extraction at baseline. Serum levels of IL-1β, IL-6, IL-8, IL-17, MCP-1, TNF-α, IL-10, and VEGF were determined by Luminex. Tregs population, defined as CD3 + CD4 + FoxP3 + in PBMC, was determined by flow cytometry. Main outcome measure was the predictive association between searched mediators and CST sustained improvement, defined as CST < 300 microns or a 20% CST decrease, at 6 months maintained until 12-months compared to baseline levels. Multivariate logistic regression analysis showed an association between CST sustained improvement at 12 months follow-up and IL-6 and Tregs baseline levels. Higher IL-6 levels were associated with less events of UME improvement (OR: 0. 67, 95% CI (0. 45-1. 00), P = 0. 042), whereas higher levels of Tregs favored such improvement (OR: 1. 25, 95% CI: 1. 12-2. 56, P = 0. 049). Increased levels of Tregs and reduced levels of IL-6 in serum may be prognostic factors of sustained anatomical improvement in UME. These findings could enforce the opportunity to develop more efficient and personalized therapeutic approaches to improve long-term visual prognosis in patients with UME.
Ayudas:	Ministerio de Economía y Competitividad PI13/00217 Ministerio de Economía y Competitividad RD16/0008 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR0701
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Macular edema ; Uveitis ; Cytokines ; Regulatory T cells ; Biomarkers
Publicado en:	Frontiers in immunology, Vol. 11 (september 2020) , ISSN 1664-3224

DOI: 10.3389/fimmu.2020.579005
PMID: 33101305

9 p, 605.3 KB

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