The Emerging Role of the Lysosome in Parkinson's Disease
Navarro-Romero, Alba (Universitat Autònoma de Barcelona)
Montpeyó Garcia-Moreno, Marta (Universitat Autònoma de Barcelona)
Martinez-Vicente, Marta (Universitat Autònoma de Barcelona)

Fecha:	2020
Resumen:	Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson's disease (PD). Lysosomes are the converging step where the substrates delivered by autophagy and endocytosis are degraded in order to recycle their primary components to rebuild new macromolecules. Genetic studies have revealed the important link between the lysosomal function and PD; several of the autosomal dominant and recessive genes associated with PD as well as several genetic risk factors encode for lysosomal, autophagic, and endosomal proteins. Mutations in these PD-associated genes can cause lysosomal dysfunction, and since α-synuclein degradation is mostly lysosomal-dependent, among other consequences, lysosomal impairment can affect α-synuclein turnover, contributing to increase its intracellular levels and therefore promoting its accumulation and aggregation. Recent studies have also highlighted the bidirectional link between Parkinson's disease and lysosomal storage diseases (LSD); evidence includes the presence of α-synuclein inclusions in the brain regions of patients with LSD and the identification of several lysosomal genes involved in LSD as genetic risk factors to develop PD.
Ayudas:	Instituto de Salud Carlos III PI17/00496 Ministerio de Economía y Competitividad FPU18/05595
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Parkinson's disease ; Lysosomes ; Autophagy ; Lysosomal storage diseases ; Endocytosis ; Glucocerebrosidase ; Α-synuclein
Publicado en:	Cells, Vol. 9 (november 2020) , ISSN 2073-4409

DOI: 10.3390/cells9112399
PMID: 33147750

25 p, 864.4 KB

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