Antibiotics as Major Disruptors of Gut Microbiota
Ramirez, Jaime (Universidad Nacional Autónoma de México)
Guarner, Francisco (Hospital Universitari Vall d'Hebron)
Bustos Fernandez, Luis (Centro Medico Bustos Fernandez (CMBF))
Maruy, Aldo (Hospital Arnau de Vilanova (València))
Sdepanian, Vera Lucia (Universidade Federal de São Paulo)
Cohen, Henry (National School of Medicine)
Universitat Autònoma de Barcelona

Fecha:	2020
Resumen:	Advances in culture-independent research techniques have led to an increased understanding of the gut microbiota and the role it plays in health and disease. The intestine is populated by a complex microbial community that is organized around a network of metabolic interdependencies. It is now understood that the gut microbiota is vital for normal development and functioning of the human body, especially for the priming and maturation of the adaptive immune system. Antibiotic use can have several negative effects on the gut microbiota, including reduced species diversity, altered metabolic activity, and the selection of antibiotic-resistant organisms, which in turn can lead to antibiotic-associated diarrhea and recurrent Clostridioides difficile infections. There is also evidence that early childhood exposure to antibiotics can lead to several gastrointestinal, immunologic, and neurocognitive conditions. The increase in the use of antibiotics in recent years suggests that these problems are likely to become more acute or more prevalent in the future. Continued research into the structure and function of the gut microbiota is required to address this challenge.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Antibiotic overuse ; Antibiotic resistance ; Gut microbiota ; Microbial diversity ; Antibiotic-associated diarrhea (AAD) ; Enterotypes
Publicado en:	Frontiers in cellular and infection microbiology, Vol. 10 (november 2020) , ISSN 2235-2988

DOI: 10.3389/fcimb.2020.572912
PMID: 33330122

10 p, 592.1 KB

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