Linear Growth in Pediatric Kidney Transplant Population
Lopez-Gonzalez, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Munoz, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Perez-Beltran, Victor (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Cruz, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Gander, Romy (Hospital Universitari Vall d'Hebron)
Ariceta Iraola, Gema (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)

Date:	2020
Abstract:	Introduction: Growth retardation is one of the main complications of chronic kidney disease (CKD) in children and induces a negative impact on quality of life. Materials and Methods: Retrospective analysis of all consecutive patients younger than 18 years old who received a first KT in our center between 2008 and 2018. Results: 95 first KT recipients, median age at KT of 7. 83 years. At the time of KT, 65. 52% of males and 54. 05% females showed normal height. After transplantation, linear growth improved from −1. 53 at transplant to −1. 37 SDS height at the last visit. We detected a different linear growth pattern according to patient age at KT. Children younger than 3 years old exhibited the most significant growth retardation at baseline and the greatest linear growth over time (−2. 29 vs. −1. 82 SDS height), whereas catch-up was not observed in older patients. Multivariate analysis showed that use of corticosteroids was negatively related to SDS height at 1 year after transplantation and final SDS height only was positively associated with SDS height at KT. 44. 2 and 22. 1% patients received rhGH treatment before and after KT. 71. 88% patients reached adulthood with normal final height. Conclusions: In our study, pediatric KT recipients exhibited a normal height in more than half of cases at KT and in more than two thirds at the final adult height. Only children younger than 6 years old presented a relevant growth catch-up after KT. Treatment with rhGH was used before and after KT with significant improvement in height.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Growth ; Pediatric ; Kidney transplant ; Height ; Growth hormone
Published in:	Frontiers in Pediatrics, Vol. 8 (december 2020) , ISSN 2296-2360

DOI: 10.3389/fped.2020.569616
PMID: 33364221

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