Connexins : Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease
Aasen, Trond (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Johnstone, Scott (University of Glasgow)
Vidal-Brime, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Lynn, K. Sabrina (Emory University School of Medicine)
Koval, Michael (Emory University School of Medicine)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to these proteins. The connexin gene family is under extensive regulation at the transcriptional and post-transcriptional level, and undergoes numerous modifications at the protein level, including phosphorylation, which ultimately affects their trafficking, stability, and function. Here, we summarize these key regulatory events, with emphasis on how these affect connexin multifunctionality in health and disease.
Grants:	Ministerio de Economía y Competitividad PI13/00763 Ministerio de Economía y Competitividad PI16/00772 Instituto de Salud Carlos III PII16/0004
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Connexins ; Gap junctions ; Transcription ; Translation ; Post-translational modifications ; Trafficking
Published in:	International journal of molecular sciences, Vol. 19 (april 2018) , ISSN 1422-0067

DOI: 10.3390/ijms19051296
PMID: 29701678

36 p, 1.9 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles