SSAO/VAP-1 in Cerebrovascular Disorders : A Potential Therapeutic Target for Stroke and Alzheimer's Disease
Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Sun, Ping (University of Pittsburgh School of Medicine)
Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron. Institut de Recerca)

Date:	2021
Abstract:	The semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1) or primary amine oxidase (PrAO), is a deaminating enzyme highly expressed in vessels that generates harmful products as a result of its enzymatic activity. As a multifunctional enzyme, it is also involved in inflammation through its ability to bind and promote the transmigration of circulating leukocytes into inflamed tissues. Inflammation is present in different systemic and cerebral diseases, including stroke and Alzheimer's disease (AD). These pathologies show important affectations on cerebral vessels, together with increased SSAO levels. This review summarizes the main roles of SSAO/VAP-1 in human physiology and pathophysiology and discusses the mechanisms by which it can affect the onset and progression of both stroke and AD. As there is an evident interrelationship between stroke and AD, basically through the vascular system dysfunction, the possibility that SSAO/VAP-1 could be involved in the transition between these two pathologies is suggested. Hence, its inhibition is proposed to be an interesting therapeutical approach to the brain damage induced in these both cerebral pathologies.
Grants:	Ministerio de Economía y Competitividad RD16/0019/0021
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	SSAO/VAP-1 ; Stroke ; Alzheimer's disease ; Vascular damage ; Blood-brain barrier dysfunction ; Neurovascular unit ; Inflammation ; Oxidative stress
Published in:	International journal of molecular sciences, Vol. 22 (march 2021) , ISSN 1422-0067

DOI: 10.3390/ijms22073365
PMID: 33805974

30 p, 1.3 MB

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