Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients
Marin-Corral, Judith (Institut Hospital del Mar d'Investigacions Mèdiques)
Rodríguez-Morató, Jose (Institut Hospital del Mar d'Investigacions Mèdiques)
Gomez-Gomez, A (Institut Hospital del Mar d'Investigacions Mèdiques)
Pascual-Guardia, Sergi (Institut Hospital del Mar d'Investigacions Mèdiques)
Muñoz-Bermúdez, Rosana (Institut Hospital del Mar d'Investigacions Mèdiques)
Salazar-Degracia, Anna (Institut Hospital del Mar d'Investigacions Mèdiques)
Pérez-Terán, Purificación (Institut Hospital del Mar d'Investigacions Mèdiques)
Restrepo, Marcos I. (South Texas Veterans Health Care System)
Khymenets, Olha (Institut Hospital del Mar d'Investigacions Mèdiques)
Haro, Noemí (Institut Hospital del Mar d'Investigacions Mèdiques)
Masclans, Joan R. (Institut Hospital del Mar d'Investigacions Mèdiques)
Pozo, Oscar J. (Institut Hospital del Mar d'Investigacions Mèdiques)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 pathophysiology, and guide clinical decisions. This study aimed at assessing the critical metabolic pathways altered with disease severity in hospitalized COVID-19 patients. Forty-nine hospitalized patients with COVID-19 pneumonia were enrolled in a prospective, observational, single-center study in Barcelona, Spain. Demographic, clinical, and analytical data at admission were registered. Plasma samples were collected within the first 48 h following hospitalization. Patients were stratified based on the severity of their evolution as moderate (N = 13), severe (N = 10), or critical (N = 26). A panel of 221 biomarkers was measured by targeted metabolomics in order to evaluate metabolic changes associated with subsequent disease severity. Our results show that obesity, respiratory rate, blood pressure, and oxygen saturation, as well as some analytical parameters and radiological findings, were all associated with disease severity. Additionally, ceramide metabolism, tryptophan degradation, and reductions in several metabolic reactions involving nicotinamide adenine nucleotide (NAD) at inclusion were significantly associated with respiratory severity and correlated with inflammation. In summary, assessment of the metabolomic profile of COVID-19 patients could assist in disease severity stratification and even in guiding clinical decisions.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	COVID-19 ; Metabolomics ; Severity ; Kynurenine ; Ceramides
Published in:	International journal of molecular sciences, Vol. 22 (april 2021) , ISSN 1422-0067

DOI: 10.3390/ijms22094794
PMID: 33946479

14 p, 2.4 MB

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