Behavioral and metabolic effects of a calorie-restricted cafeteria diet and oleuropein supplementation in obese male rats
Subias-Gusils, Alex (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Álvarez-Monell, Adam (Universitat Autònoma de Barcelona. Institut de Neurociències)
Boqué, Noemí (Eurecat. Centre Tecnològic de Catalunya)
Caimari, Antoni (Eurecat. Centre Tecnològic de Catalunya)
del Bas, Josep Maria (Eurecat. Centre Tecnològic de Catalunya)
Mariné-Casadó, Roger (Eurecat. Centre Tecnològic de Catalunya)
Solanas i Garcia, Montserrat (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Escorihuela, Rosa M. (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2021
Abstract:	Diet-induced obesity models are widely used to investigate dietary interventions for treating obesity. This study was aimed to test whether a dietary intervention based on a calorie-restricted cafeteria diet (CAF-R) and a polyphenolic compound (Oleuropein, OLE) supplementation modified sucrose intake, preference, and taste reactivity in cafeteria diet (CAF)-induced obese rats. CAF diet consists of high-energy, highly palatable human foods. Male rats fed standard chow (STD) or CAF diet were compared with obese rats fed CAF-R diet, alone or supplemented with an olive tree leaves extract (25 mg/kg*day) containing a 20. 1% of OLE (CAF-RO). Biometric, food consumption, and serum parameters were measured. CAF diet increased body weight, food and energy consumption and obesity-associated metabolic parameters. CAF-R and CAF-RO diets significantly attenuated body weight gain and BMI, diminished food and energy intake and improved biochemical parameters such as triacylglycerides and insulin resistance which did not differ between CAF-RO and STD groups. The three cafeteria groups diminished sucrose intake and preference compared to STD group. CAF-RO also diminished the hedonic responses for the high sucrose concentrations compared with the other groups. These results indicate that CAF-R diet may be an efficient strategy to restore obesity-associated alterations, whilst OLE supplementation seems to have an additional beneficial effect on sweet taste function.
Grants:	Ministerio de Economía y Competitividad PSI2016-77234-R Agencia Estatal de Investigación PID2020-119391GB-I00 Ministerio de Ciencia e Innovación BES-2017-08193
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Diet-induced obesity ; Energy restriction ; Food intake ; Hedonic response ; Leptin ; Polyphenols ; Sucrose preference ; Sweet taste
Published in:	Nutrients, Vol. 13 Núm. 12 (december 2021) , p. 4474, ISSN 2072-6643

DOI: 10.3390/nu13124474
PMID: 34960026

17 p, 1.7 MB

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