Molecular and Cellular Mechanisms of M. tuberculosis and SARS-CoV-2 Infections-Unexpected Similarities of Pathogenesis and What to Expect from Co-Infection
Starshinova, Anna A. (Almazov National Medical Research Centre)
Kudryavtsev, Igor (Institute of Experimental Medicine (Rússia))
Malkova, Anna (St. Petersburg State University)
Zinchenko, Ulia (St. Petersburg Research Institute of Phthisiopulmonology)
Karev, Vadim (Children's Clinical Research Center for Infectious Diseases, 197022 St. Petersburg, Russia)
Kudlay, Dmitry (Institute of Immunology, 115478 Moscow, Russia)
Glushkova, Angela (V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology)
Starshinova, Anastasiya Y. (St. Petersburg State Pediatric Medical University)
Domínguez, José (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Villar-Hernández, Raquel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Dovgalyk, Irina (St. Petersburg Research Institute of Phthisiopulmonology)
Yablonskiy, Piotr (St. Petersburg Research Institute of Phthisiopulmonology)

Fecha:	2022
Resumen:	Tuberculosis is still an important medical and social problem. In recent years, great strides have been made in the fight against M. tuberculosis, especially in the Russian Federation. However, the emergence of a new coronavirus infection (COVID-19) has led to the long-term isolation of the population on the one hand and to the relevance of using personal protective equipment on the other. Our knowledge regarding SARS-CoV-2-induced inflammation and tissue destruction is rapidly expanding, while our understanding of the pathology of human pulmonary tuberculosis gained through more the 100 years of research is still limited. This paper reviews the main molecular and cellular differences and similarities caused by M. tuberculosis and SARS-CoV-2 infections, as well as their critical immunological and pathomorphological features. Immune suppression caused by the SARS-CoV-2 virus may result in certain difficulties in the diagnosis and treatment of tuberculosis. Furthermore, long-term lymphopenia, hyperinflammation, lung tissue injury and imbalance in CD4+ T cell subsets associated with COVID-19 could propagate M. tuberculosis infection and disease progression.
Ayudas:	European Commission. Horizon 2020 823854
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Tuberculosis ; SARS-CoV-2 infection ; COVID-19 ; M. tuberculosis infection ; Th cell subsets
Publicado en:	International journal of molecular sciences, Vol. 23 (february 2022) , ISSN 1422-0067

DOI: 10.3390/ijms23042235
PMID: 35216349

14 p, 2.7 MB

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