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| Home > Articles > Published articles > Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder : |
(Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Centro de Investigación Biomédica en Red de Salud Mental) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Centro de Investigación Biomédica en Red de Salud Mental) (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació) (Centro de Investigación Biomédica en Red de Salud Mental) (Centro de Investigación Biomédica en Red de Salud Mental) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
| Date: | 2021 |
| Abstract: | Background: Bipolar Disorder (BD) and Borderline Personality Disorder (BPD) have clinically been evolving as separate disorders, though there is still debate on the nosological valence of both conditions, their interaction in terms of co-morbidity or disorder spectrum and their distinct pathophysiology. Objective: The objective of this review is to summarize evidence regarding clinical features, neuropsychological performance and neuroimaging findings from cross-diagnostic studies comparing BD and BPD, to further caracterize their complex interplay. Methods: Using PubMed, PsycINFO and TripDataBase, we conducted a systematic literature search based on PRISMA guidelines of studies published from January 1980 to September 2019 which directly compared BD and BPD. Results: A total of 28 studies comparing BD and BPD were included: 19 compared clinical features, 6 neuropsychological performance and three neuroimaging abnormalities. Depressive symptoms have an earlier onset in BPD than BD. BD patients present more mixed or manic symptoms, with BD-I differing from BPD in manic phases. BPD patients show more negative attitudes toward others and self, more conflictive interpersonal relationships, and more maladaptive regulation strategies in affective instability with separate pathways. Impulsivity seems more a trait in BPD rather than a state as in BD. Otherwise, BD and BPD overlap in depressive and anxious symptoms, dysphoria, various abnormal temperamental traits, suicidal ideation, and childhood trauma. Both disorders differ and share deficits in neuropsychological and neuroimaging findings. Conclusion: Clinical data provide evidence of overlapping features in both disorders, with most of those shared symptoms being more persistent and intense in BPD. Thus, categorical classifications should be compared to dimensional approaches in transdiagnostic studies investigating BPD features in BD regarding their respective explanatory power for individual trajectories. Systematic Review Registration: The search strategy was pre-registered in PROSPERO: CRD42018100268. |
| Grants: | Instituto de Salud Carlos III PI/15/02242 Instituto de Salud Carlos III PI18/00009 Instituto de Salud Carlos III FI10/00017 Generalitat de Catalunya PERIS; G60072253 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017_SGR_134 Ministerio de Economía y Competitividad PI15/00588 Ministerio de Economía y Competitividad PI19/00009 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Bipolar disorder ; Borderline personality disorder ; Clinical features ; Cognitive functions ; Neuroimaging ; Affective continuum |
| Published in: | Frontiers in psychiatry, Vol. 12 (june 2021) , ISSN 1664-0640 |
