Benznidazole Treatment : Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain
Fonseca, Kátia da Silva (Federal University of Ouro Preto)
Perin, Luísa (University of Ouro Preto)
de Paiva, Nívia Carolina Nogueira (Federal University of Ouro Preto)
da Silva, Beatriz Cristiane (Federal University of Ouro Preto)
Duarte, Thays Helena Chaves (Federal University of Ouro Pretotment of Biological Sciences, Nucleus of Biological Sciences Research)
Marques, Flávia de Souza (Federal University of Ouro Preto)
Costa, Guilherme de Paula (Federal University of Ouro Preto)
Molina Romero, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Correa-Oliveira, Rodrigo (Fundação Oswaldo Cruz (Brasil))
Vieira, Paula Melo de Abreu (Federal University of Ouro Preto)
Carneiro, Cláudia Martins (Federal University of Ouro Preto)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	As the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. Therefore, we evaluated the efficacy of different therapeutic schemes with benznidazole (BNZ) on the acute and chronic phases of the disease, using mice infected with strains that have different BNZ susceptibilities. Our results show that the groups of animals infected by VL-10 strain, when treated in the chronic phase with a lower dose of BNZ for a longer period of time (40 mg/kg/day for 40 days) presented better treatment efficacy than with the standard protocol (100 mg/kg/day for 20 days) although the best result in the treatment of the animals infected by the VL-10 strain was with100 mg/kg/day for 40 days. In the acute infection by the Y and VL-10 strains of T. cruzi, the treatment with a standard dose, but with a longer time of treatment (100 mg/kg/day for 40 days) presented the best results. Given these data, our results indicate that for BNZ, the theory of dose and time proportionality does not apply to the phases of infection.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Chagas disease ; Trypanosoma cruzi ; Benznidazole ; Therapeutic strategies ; Mice
Publicado en:	Pathogens, Vol. 10 (june 2021) , ISSN 2076-0817

DOI: 10.3390/pathogens10060729
PMID: 34207764

10 p, 1.3 MB

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