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Página principal > Artículos > Artículos publicados > Antibacterial films based on MOF composites that release iodine passively or upon triggering by near-infrared light |
Fecha: | 2022 |
Resumen: | Multidrug-resistant bacteria have become a global health problem for which new prophylactic strategies are now needed, including surface-coatings for hospital spaces and medical equipment. This work reports the preparation and functional validation of a metal-organic framework (MOF) based composite for the triggered controlled release of iodine, an antimicrobial element that does not generate resistance. It comprises beads of the iodophilic MOF UiO-66 containing encapsulated gold nanorods (AuNRs) coated with a silica shell. Irradiation of the AuNRs with near-infrared light (NIR) provokes a photothermal effect and the resultant heat actively liberates the iodine. After validating the performance of this composite, it is integrated into a polymer for the development of antibacterial films. This work assesses the adsorption of iodine into these composite films, as well as its passive long-term release and active light-triggered. Finally, this work validates the antibacterial activity of the composite films in vitro against gram-positive and gram-negative bacteria. The findings will surely inform the development of new prophylactic treatments. |
Ayudas: | European Commission 615954 Agencia Estatal de Investigación RTI2018-095622-B-I00 Agencia Estatal de Investigación RTI2018-099965-B-I00 Agencia Estatal de Investigación BES-2017-083043 Ministerio de Economía y Competitividad SEV-2017-0706 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-238 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1431 |
Nota: | This work was supported by the CERCA Program/Generalitat de Catalunya. |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Antimicrobial ; Composites ; Gold nanorods ; Iodine ; Metal-organic frameworks ; Photothermal ; Triggered release |
Publicado en: | Advanced functional materials, Vol. 32, issue 19 (May 2022) , art. 2112902, ISSN 1616-3028 |
13 p, 4.0 MB |