Probing the immune responses to nanoparticles across environmental species. A perspective of the EU Horizon 2020 project PANDORA
Pinsino, Annalisa (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo))
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia)
Busquets-Fité, Martí (Applied Nanoparticles S.L.)
Canesi, Laura (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita)
Cesaroni, Paola (ALTA S.r.l.u)
Drobne, Damjana (Univerza V Ljubljani. Oddelek za biologijo)
Duschl, Albert (Paris-Lodron University Salzburg. Department of Biosciences)
Ewart, Marie-Ann (AvantiCell Science Ltd)
Gispert, Ignasi (Applied Nanoparticles S.L.)
Horejs-Hoeck, Jutta (Paris-Lodron University Salzburg. Department of Biosciences)
Italiani, Paola (Stazione Zoologica Anton Dohrn)
Kemmerling, Birgit (Eberhard-Karls University Tübingen. Center for Plant Molecular Biology-ZMBP)
Kille, Peter (Cardiff University. School of Biosciences)
Procházková, Petra (Institute of Microbiology of the Czech Academy of Sciences)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Spurgeon, David J. (UK Centre for Ecology and Hydrology)
Svendsen, Claus (UK Centre for Ecology and Hydrology)
Wilde, Colin J. (AvantiCell Science Ltd)
Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols))

Fecha:	2020
Resumen:	Understanding how engineered nanomaterials affect immune responses of living organisms requires a strong collaborative effort between immunologists, toxicologists, ecologists, physiologists, inorganic chemists, nanomaterial scientists and experts in law and risk management. This perspective aims to provide a new viewpoint on the interaction between engineered nanomaterials and the immune defensive systems across living species, gained within the EU Horizon 2020 project PANDORA. We consider the effects of nanoparticle exposure on immune functions in plants, marine and terrestrial invertebrates and their relation to the current state of knowledge for vertebrates (in particular humans). These studies can shed light on the broader perspective of defensive and homeostatic mechanisms (immunity, inflammation, stress responses, microbiota, stem cell differentiation) suggesting ways to: i) perform a comparative analysis of the nanoparticle impact on immunity across model organisms; ii) inspire best practices in experimental methodologies for nanosafety/nanotoxicity studies; iii) regroup and harmonise fragmented research activities; iv) improve knowledge transfer strategies and nano-security; v) propose innovative tools and realistic solutions, thereby helping in identifying future research needs and tackling their challenges.
Ayudas:	European Commission 671881
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Comparative analysis ; Engineered nanomaterials ; Environmental species ; Experimental methodology ; Homeostatic mechanism ; Nanoparticle exposures ; Stem cell differentiation ; Terrestrial invertebrate
Publicado en:	Environmental science. Nano, Vol. 7, issue 11 (Nov. 2020) , p. 3216-3232, ISSN 2051-8161

DOI: 10.1039/d0en00732c

17 p, 3.1 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Nanociència i Nanotecnologia (ICN2)
Artículos > Artículos de investigación
Artículos > Artículos publicados