Fecal Microbiota and Hair Glucocorticoid Concentration Show Associations with Growth during Early Life in a Pig Model
González Solé, Francesc (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Solà Oriol, David (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Villagómez Estrada, Sandra (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Melo Duran, Diego Alexander (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
López, Laura Victoria (Universitat Autònoma de Barcelona. Servei de Nutrició i Benestar Animal)
Villarroel Román, Nathaly (Universitat Autònoma de Barcelona. Servei de Nutrició i Benestar Animal)
López-Arjona, Marina (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Pérez Hernández, José Francisco (Universitat Autònoma de Barcelona. Grup de Recerca de Nutrició Maneig i Benestar Animal)

Publicación:	Multidisciplinary Digital Publishing Institute (MDPI), 2022
Resumen:	Identifying characteristics associated with fast or slow growth during early life in a pig model will help in the design of nutritional strategies or recommendations during infancy. The aim of this study was to identify if a differential growth during lactation and/or the nursery period may be associated with fecal microbiota composition and fermentation capacity, as well as to leave a print of glucocorticoid biomarkers in the hair. Seventy-five commercial male and female pigs showing extreme growth in the lactation and nursery periods were selected, creating four groups (First, lactation growth, d0-d21; second, nursery growth, d21-d62): Slow_Slow, Slow_Fast, Fast_Slow, and Fast_Fast. At d63 of life, hair and fecal samples were collected. Fast-growing pigs during nursery had higher cortisone concentrations in the hair (p < 0. 05) and a tendency to have a lower cortisol-to-cortisone ratio (p = 0. 061). Both lactation and nursery growth conditioned the fecal microbiota structure (p < 0. 05). Additionally, fast-growing pigs during nursery had higher evenness (p < 0. 05). Lactation growth influenced the relative abundance of eight bacterial genera, while nursery growth affected only two bacterial genera (p < 0. 05). The fecal butyrate concentration was higher with fast growth in lactation and/or nursery (p < 0. 05), suggesting it has an important role in growth, while total SCFA and acetate were related to lactation growth (p < 0. 05). In conclusion, piglets' growth during nursery and, especially, the lactation period was associated with changes in their microbiota composition and fermentation capacity, evidencing the critical role of early colonization on the establishment of the adult microbiota. Additionally, cortisol conversion to cortisone was increased in animals with fast growth, but further research is necessary to determine its implications.
Ayudas:	Ministerio de Economía, Industria y Competitividad AGL_PID2020-113604RB Ministerio de Ciencia, Innovación y Universidades FPU18/00401
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Lactation Growth ; Nursery Growth ; Pig ; Short-chain fatty acids ; Cortisol ; Cortisone ; Fecal Microbiota
Publicado en:	Nutrients, ISSN 2072-6643

DOI: 10.3390/nu14214639
PMID: 36364901

19 p, 1.3 MB

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