Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota
Barber, Claudia (Universitat Autònoma de Barcelona. Departament de Medicina)
Sabater, Carlos (Health Research Institute of Asturias)
Ávila-Gálvez, María Ángeles (Laboratory of Food & Health, Group of Quality, Safety, and Bioactivity of Plant Foods (Múrcia))
Vallejo, Fernando (Metabolomics Service (Múrcia))
Bendezú García, Rogger Álvaro (Hospital General de Catalunya)
Guérin-Deremaux, Laetitia (Roquette Frères)
Guarner, Francisco (Hospital Universitari Vall d'Hebron)
Espín, Juan Carlos (Laboratory of Food & Health, Group of Quality, Safety, and Bioactivity of Plant Foods (Múrcia))
Margolles, Abelardo (Health Research Institute of Asturias)
Azpiroz Vidaur, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)

Fecha:	2022
Resumen:	Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety. Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition. Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE ®, Roquette Frères, Lestrem, France) for four weeks. Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine. Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation. Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism. These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
Ayudas:	Ministerio de Ciencia e Innovación PID2021-122295OB-I00 Agencia Estatal de Investigación PID2019-103914RB-I00 Ministerio de Ciencia e Innovación AGL2016-78311-R Ministerio de Ciencia e Innovación FJC2019-042125-I
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Prebiotic ; Gut microbiota ; Metagenomics ; Metabolomics ; Digestive sensations ; Intestinal gas ; Resistant dextrin
Publicado en:	Nutrients, Vol. 14 (november 2022) , ISSN 2072-6643

DOI: 10.3390/nu14214611
PMID: 36364873

22 p, 2.7 MB

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