Dietary and/or physical activity interventions in women with overweight or obesity prior to fertility treatment : protocol for a systematic review and individual participant data meta-analysis
Evans-Hoeker, Emily (Shady Grove Fertility, Roanoke, Virginia, USA)
Wang, Zheng (University Medical Centre Groningen)
Groen, Henk (University Medical Centre Groningen)
Cantineau, Astrid (University Medical Centre Groningen)
Thurin-Kjellberg, Ann (Sahlgrenska University Hospital (Suècia))
Bergh, Christina (Sahlgrenska University Hospital (Suècia))
Laven, Joop S E (Erasmus University Medical Center)
Dietz de Loos, Alexandra (Erasmus University Medical Center)
Jiskoot, Geranne (Erasmus University Medical Center, Rotterdam)
Baillargeon, Jean-Patrice (Université de Sherbrooke, Quebec, Canada)
Palomba, Stefano (University "Magna Graecia" of Catanzaro, Catanzaro, Italy)
Sim, Kyra (Royal Prince Alfred Hospital, Sydney, New South Wales, Australia)
Moran, Lisa J (Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia)
Espinós, Juan José (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Moholdt, Trine (St Olavs Hospital Trondheim University Hospital, Trondheim, Trøndelag, Norway)
Rothberg, Amy E (University of Michigan, Ann Arbor, Michigan, USA)
Shoupe, Donna (University of Southern California Keck School of Medicine, Los Angeles, California, USA)
Hoek, Annemieke (University Medical Centre Groningen)
Legro, Richard S (Penn State College of Medicine, Hershey, Pennsylvania, USA)
Mol, Ben Willem J (University of Aberdeen School of Medicine Medical Sciences and Nutrition)
Wang, Rui (Monash University, Clayton, Victoria, Australia)

Date:	2022
Abstract:	Dietary and/or physical activity interventions are often recommended for women with overweight or obesity as the first step prior to fertility treatment. However, randomised controlled trials (RCTs) so far have shown inconsistent results. Therefore, we propose this individual participant data meta-analysis (IPDMA) to evaluate the effectiveness and safety of dietary and/or physical activity interventions in women with infertility and overweight or obesity on reproductive, maternal and perinatal outcomes and to explore if there are subgroup(s) of women who benefit from each specific intervention or their combination (treatment-covariate interactions). We will include RCTs with dietary and/or physical activity interventions as core interventions prior to fertility treatment in women with infertility and overweight or obesity. The primary outcome will be live birth. We will search MEDLINE, Embase, Cochrane Central Register of Controlled Trials and trial registries to identify eligible studies. We will approach authors of eligible trials to contribute individual participant data (IPD). We will perform risk of bias assessments according to the Risk of Bias 2 tool and a random-effects IPDMA. We will then explore treatment-covariate interactions for important participant-level characteristics. Formal ethical approval for the project (Venus-IPD) was exempted by the medical ethics committee of the University Medical Center Groningen (METc code: 2021/563, date: 17 November 2021). Data transfer agreement will be obtained from each participating institute/hospital. Outcomes will be disseminated internationally through the collaborative group, conference presentations and peer-reviewed publication. CRD42021266201.
Note:	Altres ajuts: National Health and Medical Research Council (2009767)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Subfertility ; NUTRITION & DIETETICS ; SPORTS MEDICINE ; Reproductive medicine ; PERINATOLOGY
Published in:	BMJ open, Vol. 12 (november 2022) , ISSN 2044-6055

DOI: 10.1136/bmjopen-2022-065206
PMID: 36344004

6 p, 544.1 KB

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